Emerging roles of PPARS in inflammation and immunity

• Published in: Nature reviews. Immunology Vol. 2; no. 10; pp. 748 - 759
• Main Authors: Daynes, Raymond A, Jones, Dallas C
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01-10-2002
• Subjects: Animals; B-Lymphocytes - immunology; B-Lymphocytes - metabolism; Cloning; Dendritic Cells - immunology; Dendritic Cells - metabolism; Humans; Immunity, Innate; Inflammation - drug therapy; Inflammation - etiology; Ligands; Lipids; Liver; Metabolism; Models, Immunological; Receptors, Cytoplasmic and Nuclear - chemistry; Receptors, Cytoplasmic and Nuclear - immunology; Receptors, Cytoplasmic and Nuclear - physiology; Signal Transduction; T-Lymphocytes - immunology; T-Lymphocytes - metabolism; Transcription factors; Transcription Factors - chemistry; Transcription Factors - immunology; Transcription Factors - physiology; Transcriptional Activation; United States > US; Utah
• ISSN: 1474-1733; 1474-1741
• DOI: 10.1038/nri912

Lipids and lipid metabolism have well-documented regulatory effects on inflammatory processes. Recent work has highlighted the role of the peroxisome proliferator-activated receptors (PPARs)--a subset of the nuclear-hormone-receptor superfamily that are activated by various lipid species--in regulating inflammatory responses. Here, we describe how the PPARs, through their interactions with transcription factors and other cell-signalling systems, have important regulatory roles in innate and adaptive immunity.