Linking Flavonoids to Gold - A New Family of Gold Compounds for Potential Therapeutic Applications

Linking Flavonoids to Gold - A New Family of Gold Compounds for Potential Therapeutic Applications

The flavone ligands 8‐chloro‐2‐tetrahydrofuryl‐1,4‐benzopyrone and 8‐chloro‐2‐(2‐methyltetrahydrofuryl)‐1,4‐benzopyrone have been used to prepare the first examples of alkynyl phosphine gold compounds containing flavonoids which exhibit cytotoxicity towards human prostate cancer cells. The first exa...

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Bibliographic Details
Published in:European journal of inorganic chemistry Vol. 2015; no. 25; pp. 4275 - 4279
Main Authors: Mirzadeh, Nedaossadat, Privér, Steven H., Abraham, Amanda, Shukla, Ravi, Bansal, Vipul, Bhargava, Suresh K.
Format: Journal Article
Language:English
Published: Weinheim WILEY-VCH Verlag 01-09-2015
WILEY‐VCH Verlag
Wiley Subscription Services, Inc
Subjects:
Alkyne ligands
Androgens
Antitumor ­agents
Cancer
Chemical compounds
Flavones
Flavonoids
Gold
Gold compounds
Human
Ligands
Phosphine ligands
Phosphines
Prostate
Prostate cancer
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Summary:The flavone ligands 8‐chloro‐2‐tetrahydrofuryl‐1,4‐benzopyrone and 8‐chloro‐2‐(2‐methyltetrahydrofuryl)‐1,4‐benzopyrone have been used to prepare the first examples of alkynyl phosphine gold compounds containing flavonoids which exhibit cytotoxicity towards human prostate cancer cells. The first examples of alkynyl phosphine gold compounds containing flavonoids have been synthesized. They exhibit cytotoxicity towards human prostate cancer cells.
Bibliography:ArticleID:EJIC201500514
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ark:/67375/WNG-C64RXDCP-X
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1434-1948
1099-0682
DOI:10.1002/ejic.201500514