Deanol and physostigmine in the treatment of L-dopa-induced dyskinesias

• Published in: Acta neurologica Scandinavica Vol. 58; no. 2; p. 134
• Main Authors: Lindeboom, S F, Lakke, J P
• Format: Journal Article
• Language: English
• Published: Denmark 01-08-1978
• Subjects: Aged; Clinical Trials as Topic; Deanol - therapeutic use; Double-Blind Method; Drug Evaluation; Dyskinesia, Drug-Induced - drug therapy; Ethanolamines - therapeutic use; Female; Humans; Levodopa - adverse effects; Levodopa - therapeutic use; Male; Middle Aged; Parkinson Disease - drug therapy; Physostigmine - therapeutic use; Placebos
• ISSN: 0001-6314
• DOI: 10.1111/j.1600-0404.1978.tb02871.x

Deanol and placebo were administered to 10 parkinsonian patients with levodopa-induced dyskinesias in a double-blind, crossover fashion. Deanol and placebo did not differ significantly in their effects on dyskinesias. The reported properties of deanol seem to be attributable to a placebo effect. There was no correlation with the results of the physostigmine test. Despite these disappointing results deanol remains intriguing, because in individual cases remarkable improvements on dyskinesias are reported.