Rapid ESI-MS method for examining the thermal decomposition of pharmaceuticals

A Finnigan MAT TSQ 700 triple quadrupole mass spectrometer equipped with a Harvard 22 syringe pump has been used to investigate the thermal decomposition of three common pharmaceuticals, acetaminophen, indomethacin, and mefenamic acid. In addition, comparative measurements on these same drugs were c...

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Bibliographic Details
Published in:	Journal of pharmaceutical sciences Vol. 93; no. 6; p. 1545
Main Authors:	Zhou, W, Gilpin, R K
Format:	Journal Article
Language:	English
Published:	United States 01-06-2004
Subjects:	Differential Thermal Analysis - methods Pharmaceutical Preparations - analysis Pharmaceutical Preparations - chemistry Pharmaceutical Preparations - metabolism Spectrometry, Mass, Electrospray Ionization - methods
Online Access:	Get more information
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Summary:	A Finnigan MAT TSQ 700 triple quadrupole mass spectrometer equipped with a Harvard 22 syringe pump has been used to investigate the thermal decomposition of three common pharmaceuticals, acetaminophen, indomethacin, and mefenamic acid. In addition, comparative measurements on these same drugs were carried out by HPLC after thermally degrading them at elevated temperatures in order to evaluate the usefulness of the ESI-MS as a rapid means of determining the relative stability and identifying thermal decomposition products. Similar results were obtained between the two techniques (i.e., the relative rates of decomposition were mefenamic acid > indomethacin > acetaminophen), with the advantage that the ESI-MS approach was much quicker to perform.
ISSN:	0022-3549
DOI:	10.1002/jps.20082