MG-ADL: Still a relevant outcome measure

Introduction: The aim of this analysis was to examine the performance of the Myasthenia Gravis–specific Activities of Daily Living scale (MG‐ADL) during a multicenter scale validation study. Methods: Consecutive MG patients were assessed with several MG outcome measures, including the MG‐ADL. Statis...

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Bibliographic Details
Published in:Muscle & nerve Vol. 44; no. 5; pp. 727 - 731
Main Authors: Muppidi, Srikanth, Wolfe, Gil I., Conaway, Mark, Burns, Ted M.
Format: Journal Article
Language:English
Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01-11-2011
Wiley
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Summary:Introduction: The aim of this analysis was to examine the performance of the Myasthenia Gravis–specific Activities of Daily Living scale (MG‐ADL) during a multicenter scale validation study. Methods: Consecutive MG patients were assessed with several MG outcome measures, including the MG‐ADL. Statistical tests included descriptive analysis, Pearson correlation, and sensitivity/specificity. Results: Eighty‐seven patients completed the MG‐ADL, MG Composite (MGC), and MG 15‐item Quality of Life scale (MG‐QOL15) on the first visit, and 76 returned for the second visit. At the first visit, there was a strong positive correlation between MG‐ADL and MGC (r = 0.85, P < 0.0001) and MG‐QOL15 (r = 0.76, P < 0.0001). Correlation of the delta MG‐ADL score and physician impression of change between the visits was strong (r = 0.70, P < 0.0001). A 2‐point improvement in the MG‐ADL best predicted clinical improvement. Test–retest analysis demonstrated a high reliability coefficient. Conclusions: The MG‐ADL correlates strongly with newer, validated MG outcome measures. A 2‐point improvement in the MG‐ADL indicates clinical improvement. The MG‐ADL is useful as a research tool and in routine clinical management. Muscle Nerve, 2011
Bibliography:istex:FAFAA768DD286CC406CD138C1A584267D2B506DB
ark:/67375/WNG-103L0426-6
ArticleID:MUS22140
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0148-639X
1097-4598
DOI:10.1002/mus.22140