Solid-phase combinatorial synthesis and cytotoxicity of 3-aryl-2,4-quinazolindiones

• Published in: Bioorganic & medicinal chemistry Vol. 10; no. 3; pp. 517 - 523
• Main Authors: Park Choo, Hea-Young, Kim, Mihyun, Lee, Sang Kook, Woong Kim, Sang, Kwon Chung, In
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01-03-2002; Elsevier Science
• Subjects: Antineoplastic agents; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Biological and medical sciences; Cell Division - drug effects; Combinatorial Chemistry Techniques; Drug Screening Assays, Antitumor; General aspects; Humans; Medical sciences; Pharmacology. Drug treatments; Quinazolines - chemical synthesis; Quinazolines - chemistry; Quinazolines - pharmacology; Quinones - chemical synthesis; Quinones - chemistry; Quinones - pharmacology; Structure-Activity Relationship; Tumor Cells, Cultured; Antineoplastic agent; Human; Carcinoma; Nitrogen heterocycle; Quinazoline derivatives; Combinatorial chemistry; Cytotoxicity; Malignant tumor; In vitro; Structure activity relation; Chemical compound library; Bicyclic compound; Phenols; Aromatic compound; Colon; Solid phase; Chemical synthesis
• ISSN: 0968-0896; 1464-3391
• DOI: 10.1016/S0968-0896(01)00299-1

A series of 3-aryl-2,4-quinazolinediones with various substitution on aromatic rings has been prepared by solid-phase synthesis. Several compounds showed cytotoxicity on human colon carcinoma (Col2) tested by SRB method.
A series of 3-aryl-2,4-quinazolinediones with various substitution on aromatic rings has been prepared by solid phase synthesis. Several compounds showed cytotoxicity on human colon carcinoma (Col2) tested by SRB method.