Impaired Brain Satiety Responses After Weight Loss in Children With Obesity

• Published in: The journal of clinical endocrinology and metabolism Vol. 107; no. 8; pp. 2254 - 2266
• Main Authors: Roth, Christian L, Melhorn, Susan J, De Leon, Mary Rosalynn B, Rowland, Maya G, Elfers, Clinton T, Huang, Alyssa, Saelens, Brian E, Schur, Ellen A
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 14-07-2022
• Subjects: Behavior Therapy - methods; Behavioral health care; Body weight; Brain; Brain - diagnostic imaging; Child; Child psychopathology; Children; Clinical; Family Relations; Female; Gastrointestinal Hormones - blood; Ghrelin - blood; Glucagon; Health aspects; Humans; Insulin resistance; Male; Obesity - psychology; Obesity - therapy; Obesity in children; Peptide YY - blood; Postprandial Period - physiology; Satiety Response; Type 2 diabetes; Tyrosine; Weight Loss; meal responses; behavioral intervention; functional neuroimaging; hormonal changes; childhood obesity
• ISSN: 0021-972X; 1945-7197; 1945-7197
• DOI: 10.1210/clinem/dgac299

Obesity interventions often result in increased motivation to eat.
We investigated relationships between obesity outcomes and changes in brain activation by visual food cues and hormone levels in response to obesity intervention by family-based behavioral treatment (FBT).
Neuroimaging and hormone assessments were conducted before and after 24-week FBT intervention in children with obesity (OB, n = 28), or children of healthy weight without intervention (HW, n = 17), all 9- to 11-year-old boys and girls. We evaluated meal-induced changes in neural activation to high- vs low-calorie food cues across appetite-processing brain regions and gut hormones.
Among children with OB who underwent FBT, greater declines of BMI z-score were associated with lesser reductions after the FBT intervention in meal-induced changes in neural activation to high- vs low-calorie food cues across appetite-processing brain regions (P < 0.05), and the slope of relationship was significantly different compared with children of HW. In children with OB, less reduction in brain responses to a meal from before to after FBT was associated with greater meal-induced reduction in ghrelin and increased meal-induced stimulation in peptide YY and glucagon-like peptide-1 (all P < 0.05).
In response to FBT, adaptations of central satiety responses and peripheral satiety-regulating hormones were noted. After weight loss, changes of peripheral hormone secretion support weight loss, but there was a weaker central satiety response. The findings suggest that even when peripheral satiety responses by gut hormones are intact, the central regulation of satiety is disturbed in children with OB who significantly improve their weight status during FBT, which could favor future weight regain.