Optimization and validation of a capillary zone electrophoretic method for the analysis of several angiotensin-II-receptor antagonists

We optimized a capillary zone electrophoretic method for separation of six angiotensin-II-receptor antagonists (ARA-IIs): candesartan, eprosartan, irbesartan, losartan potassium, telmisartan, and valsartan. A three-level, full-factorial design was applied to study the effect of the pH and molarity o...

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Bibliographic Details
Published in:	Journal of Chromatography A Vol. 979; no. 1; pp. 323 - 333
Main Authors:	Hillaert, S, Van den Bossche, W
Format:	Journal Article Conference Proceeding
Language:	English
Published:	Amsterdam Elsevier B.V 06-12-2002 Elsevier
Subjects:	Analysis Angiotensin II - metabolism Angiotensin II receptor antagonists Angiotensin Receptor Antagonists Biological and medical sciences Electrophoresis, Capillary - methods General pharmacology Hydrogen-Ion Concentration Medical sciences Pharmaceutical Preparations - chemistry Pharmacology. Drug treatments Receptors, Angiotensin - metabolism Reference Standards Reproducibility of Results Validation Pharmaceutical analysis Experimental design Angiotensin II receptor antagonists Imidazole derivatives Tetrazole derivatives Chemical analysis Zone electrophoresis Valsartan Candesartan Non peptide compound Mobile phase Optimization Thiophene derivatives Losartan pH Tablet Eprosartan Antagonist Angiotensin II Quantitative analysis Phase composition Capillary electrophoresis AT1 angiotensin receptor Telmisartan Ultraviolet detector Irbesartan Benzimidazole derivatives Biphenyl derivatives Dosage form Antihypertensive agent Angiotensin antagonist Factorial design Chemometrics
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