Characterization and detection of experimental rat gliomas using magnetic resonance imaging

• Published in: Magma (New York, N.Y.) Vol. 17; no. 3-6; pp. 133 - 139
• Main Authors: Vonarbourg, A, Sapin, A, Lemaire, L, Franconi, F, Menei, P, Jallet, P, Le Jeune, J J
• Format: Journal Article
• Language: English
• Published: Germany Springer Nature B.V 01-12-2004; Springer Verlag
• Subjects: Animals; Bioengineering; Brain Neoplasms - diagnosis; Brain tumors; Diffusion coefficient; Disease Models, Animal; Female; Glioma - classification; Glioma - diagnosis; Image Enhancement - methods; Image Interpretation, Computer-Assisted - methods; Imaging; Life Sciences; Magnetic Resonance Imaging - methods; Medication; Neoplasms, Experimental - diagnosis; Pharmaceutical sciences; Rats; Rats, Inbred F344; Reproducibility of Results; Sensitivity and Specificity; Severity of Illness Index
• ISSN: 0968-5243; 1352-8661; 1352-8661
• DOI: 10.1007/s10334-004-0049-5

Two different experimental rat brain tumours (F98 glioma and 9L glioma) were characterized using T1 and T2, apparent diffusion coefficient (ADC) and magnetization transfer ratio (MTR). Even though both tumours appeared homogenous at the early stage of growth, significant differences were measured for all parametric images between tumours and normal brain tissue. Irrespective of the sequence used, tumour lesion/normal parenchyma contrast for the non-infiltrative 9L was twice that of the infiltrative F98 glioma. The use of spin preparation via an inversion pulse in a fast spin echo sequence increases contrast by a factor of 20-30.