Synthesis and investigation of tuberculosis inhibition activities of some 1,2,3-triazole derivatives

• Published in: European journal of medicinal chemistry Vol. 38; no. 2; pp. 215 - 218
• Main Authors: Dabak, Kadir, Sezer, Özkan, Akar, Ahmet, Anaç, Olcay
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Masson SAS 01-02-2003; Elsevier
• Subjects: 1,2,3-Triazoles; Anti-Infective Agents - chemical synthesis; Anti-Infective Agents - pharmacology; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antitubercular Agents - chemical synthesis; Antitubercular Agents - pharmacology; Biological and medical sciences; Medical sciences; Microbial Sensitivity Tests; Mycobacterium tuberculosis - drug effects; Pharmacology. Drug treatments; Structure-Activity Relationship; Thiadiazoles - chemical synthesis; Thiadiazoles - chemistry; Thiadiazoles - pharmacology; Tuberculosis inhibition; 1,2,3-Triazoles; Tuberculosis inhibition; Five membered ring; Nitrogen heterocycle; Benzene derivatives; Furan derivatives; Ketone; In vitro; Naphthalene derivatives; Ester; Thiophene derivatives; Mycobacterium tuberculosis; Structure activity relation; Mycobacteriales; Mycobacteriaceae; Bacteria; Actinomycetes; Antituberculous agent; Antibacterial agent; Chemical synthesis; 1,2,3,-Triazoles
• ISSN: 0223-5234; 1768-3254
• DOI: 10.1016/S0223-5234(02)01445-9

In this study, α-diazo-β-oxoaldehyde compounds were condensed with different amines to yield 4-acyl-1H-1,2,3-triazole derivatives. The 1,2,3-triazole compounds were investigated for their inhibition activities against tuberculosis.