Effect of abana (a herbal preparation) on the radiation-induced mortality in mice

• Published in: Journal of ethnopharmacology Vol. 86; no. 2; pp. 159 - 165
• Main Authors: Jagetia, Ganesh Chandra, Baliga, Manjeshwar Shrinath, Aruna, R, Rajanikant, G.K, Jain, Vikas
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 01-06-2003; Elsevier
• Subjects: Abana; Animals; Biological and medical sciences; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; General pharmacology; India; Male; Medical sciences; Medicine, Ayurvedic; Mice; Minerals - isolation & purification; Minerals - therapeutic use; Minerals - toxicity; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Plant Extracts - isolation & purification; Plant Extracts - therapeutic use; Plant Extracts - toxicity; Radiation; Radiation Injuries - mortality; Radiation Injuries - prevention & control; Survival; Toxicity; Asia; India; Abana; Mice; Toxicity; Survival; Radiation; Radioprotector; Rodentia; Extract; Biological activity; Mixture; Medicinal plant; Vertebrata; Mammalia; Mouse; Animal
• ISSN: 0378-8741; 1872-7573
• DOI: 10.1016/S0378-8741(03)00037-0

The effect of various doses (0, 5, 10, 20, 40 and 80
mg/kg body weight) of 50% ethanolic extract of abana, a traditional herbal preparation, widely used in India for the treatment of heart ailments, was studied on the radiation-induced mortality in mice exposed to 10
Gy of γ-radiation. Treatment of mice with different doses of abana delayed the onset of mortality and reduced the symptoms of radiation sickness as compared to the irradiated controls. All doses of abana provided protection against the gastrointestinal (GI) death, however, the highest protection against GI death was observed for 20
mg/kg abana. Pretreatment of mice with 20
mg/kg abana provided the best protection as evidenced by the highest number of survivors after 30 days post-irradiation in this group when compared to the other doses of abana. Acute toxic studies revealed that the abana was non-toxic up to a dose of 1.6
g/kg, where no drug-induced mortality was observed. The LD
50 dose of abana was found to be 1.8
g/kg body weight. Our study demonstrates the ability of abana as a good radioprotective agent and the optimum protective dose of abana was 1/90 of its LD
50 dose.