Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?

The molecular mechanisms that underlie tumour progression are still poorly understood, but recently our knowledge of particular aspects of some of these processes has increased. Specifically, the identification of Snail, ZEB and some basic helix-loop-helix (bHLH) factors as inducers of epithelial-me...

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Bibliographic Details
Published in:	Nature reviews. Cancer Vol. 7; no. 6; pp. 415 - 428
Main Authors:	Cano, Amparo, Peinado, Héctor, Olmeda, David
Format:	Journal Article
Language:	English
Published:	England Nature Publishing Group 01-06-2007
Subjects:	Cadherins - physiology Cell Adhesion Cell Movement Disease Progression Epithelium - physiology Growth factors Helix-Turn-Helix Motifs - physiology Homeodomain Proteins - physiology Humans Models, Biological Neoplasm Invasiveness Neoplasms - pathology Phenotype Physiological aspects Prognosis Protein Processing, Post-Translational Repressor Proteins - physiology Risk factors Signal Transduction Snail Family Transcription Factors Transcription Factors - physiology Tumors Zinc Finger E-box-Binding Homeobox 1 United States
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Summary:	The molecular mechanisms that underlie tumour progression are still poorly understood, but recently our knowledge of particular aspects of some of these processes has increased. Specifically, the identification of Snail, ZEB and some basic helix-loop-helix (bHLH) factors as inducers of epithelial-mesenchymal transition (EMT) and potent repressors of E-cadherin expression has opened new avenues of research with potential clinical implications.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	1474-175X 1474-1768
DOI:	10.1038/nrc2131