Evaluation of protective effect of bee pollen against propoxur toxicity in rat

• Published in: Ecotoxicology and environmental safety Vol. 72; no. 3; pp. 931 - 937
• Main Authors: Eraslan, Gökhan, Kanbur, Murat, Silici, Sibel, Cem Liman, Bilal, Altınordulu, Şule, Soyer Sarıca, Zeynep
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01-03-2009
• Subjects: Animals; Anti-Infective Agents - pharmacology; Bee pollen; Bees - physiology; Biochemical parameter; Biomarkers - metabolism; Blood Chemical Analysis; Drug Antagonism; Effect; Female; Insecticides - toxicity; Malondialdehyde - metabolism; Oxidative Stress - drug effects; Oxidoreductases - metabolism; Propolis - pharmacology; Propoxur; Propoxur - toxicity; Rats; Rats, Wistar; Biochemical parameter; Effect; Bee pollen; Propoxur
• ISSN: 0147-6513; 1090-2414
• DOI: 10.1016/j.ecoenv.2008.06.008

In this study, 28 Wistar female rats (200–250
g) were used and divided into four equal groups. Group 1 was allocated as the control group. Groups 2–4 were administered 100
mg/kg/bw/day bee pollen, 20
mg/kg/bw/day propoxur, and 100
mg/kg/bw/day bee pollen plus 20
mg/kg/bw/day propoxur by gavage for 14 days, respectively. At the end of the 14th day, blood and tissues (the liver, kidney, brain, and heart) were collected from all animals. Oxidative stress markers (MDA, CAT, SOD, GSH-Px) and some other biochemical parameters (total protein, albumin, glucose, cholesterol, triglyceride, BUN, creatinine, uric acid, magnesium, sodium, potassium, chloride, total bilirubin, GGT, LDH, AST, ALT, and ALP) were analyzed. According to the data obtained, propoxur was determined to lead to negative changes in most of the biochemical parameters investigated and the administration of bee pollen was determined to alleviate these effects.