Elevated Oral and Systemic Levels of Soluble Triggering Receptor Expressed on Myeloid Cells-1 (sTREM-1) in Periodontitis

• Published in: Journal of dental research Vol. 92; no. 2; pp. 161 - 165
• Main Authors: Bostanci, N., Öztürk, V.Ö., Emingil, G., Belibasakis, G.N.
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01-02-2013; SAGE PUBLICATIONS, INC
• Subjects: Aggressive Periodontitis - blood; Aggressive Periodontitis - pathology; Bacterial infections; Biomarkers; Biomarkers - analysis; Biomarkers - blood; Case-Control Studies; Cell surface; Chronic Periodontitis - blood; Chronic Periodontitis - metabolism; Cytokines; Dental Plaque Index; Dentistry; Diabetes; Disease; Enzyme-linked immunosorbent assay; Gum disease; Humans; Infections; Inflammation; Inflammation Mediators - analysis; Inflammation Mediators - blood; Interleukin-1beta - analysis; Interleukin-1beta - blood; Medicin och hälsovetenskap; Membrane Glycoproteins - analysis; Membrane Glycoproteins - blood; Myeloid cells; Myeloid Cells - metabolism; Patients; Periodontal Attachment Loss - blood; Periodontal Attachment Loss - pathology; Periodontal Index; Periodontal Pocket - blood; Periodontal Pocket - pathology; Periodontitis; Periodontium - metabolism; Receptors, Immunologic - analysis; Receptors, Immunologic - blood; Saliva; Saliva - chemistry; Sepsis; Smoking; Statistical analysis; Studies; Triggering Receptor Expressed on Myeloid Cells-1; Tumor necrosis factor-TNF; saliva; TREM-1 protein; periodontal diseases; serum; inflammation; ELISA
• ISSN: 0022-0345; 1544-0591; 1544-0591
• DOI: 10.1177/0022034512470691

The Triggering Receptor Expressed on Myeloid cells 1 (TREM-1) is a cell-surface receptor of the immunoglobulin superfamily, involved in the propagation of the inflammatory response to bacterial challenge. Soluble (s)TREM-1 is released from the cell surface during the course of infection and is a useful inflammatory biomarker in the early diagnosis of systemic sepsis. The hypothesis of this study was that oral and systemic levels of sTREM-1 are elevated in periodontitis. Therefore, the aim was to investigate, by ELISA, the sTREM-1 concentrations in saliva and serum of individuals without periodontitis (control) and persons with chronic or generalized aggressive periodontitis. In saliva, sTREM-1 concentrations were higher in chronic and aggressive periodontitis than in the control group, by 3.3-fold and 5.6-fold, respectively. In serum, these differences were 1.7-fold and 2-fold, respectively. However, there were no significant differences between the two forms of periodontitis, neither in saliva nor in serum. Salivary and serum sTREM-1 levels positively correlated with full-mouth clinical periodontal parameters. In conclusion, the increased oral and systemic levels of sTREM-1 in periodontitis denote a value for this molecule as a biomarker for the disease and may also have implications in the association between periodontal infections and systemic inflammatory response.