The NAADP receptor: commentary on Billington et al

The NAADP receptor: commentary on Billington et al

NAADP is a recently described calcium‐mobilizing messenger. First discovered as a potent calcium‐releasing molecule in sea urchin eggs, its actions have now been reported in several mammalian cell types. In the sea urchin egg, NAADP‐sensitive calcium release channels appear distinct from inositol tr...

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Bibliographic Details
Published in:British journal of pharmacology Vol. 142; no. 8; pp. 1203 - 1207
Main Authors: Galione, A, Parrington, J, Dowden, J
Format: Journal Article
Language:English
Published: Oxford, UK Blackwell Publishing Ltd 01-08-2004
Subjects:
Animals
calcium
Commentaries
cyclic ADP‐ribose
endoplasmic reticulum
Humans
inositol 1,4,5 trisphosphate
lysosome
NAADP
NADP - analogs & derivatives
NADP - chemistry
NADP - metabolism
Receptors, Cell Surface - metabolism
Structure-Activity Relationship
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Summary:NAADP is a recently described calcium‐mobilizing messenger. First discovered as a potent calcium‐releasing molecule in sea urchin eggs, its actions have now been reported in several mammalian cell types. In the sea urchin egg, NAADP‐sensitive calcium release channels appear distinct from inositol trisphosphate or ryanodine receptors, and are mainly localized to acidic compartments. In this study, Billington et al. extend the pharmacology of the putative NAADP receptor utilizing molecules unrelated to NAADP itself. This work may provide an important step in developing selective NAADP receptor modulators that will help define the role of NAADP in cell signalling. British Journal of Pharmacology (2004) 142, 1203–1207. doi:10.1038/sj.bjp.0705888
Bibliography:SourceType-Scholarly Journals-1
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ISSN:0007-1188
1476-5381
DOI:10.1038/sj.bjp.0705888