Morphology study of progesterone polymorphs prepared by polymer-induced heteronucleation (PIHn)
Summary In this article, morphology of progesterone polymorphs prepared by polymer‐induced heteronucleation (PIHn) technique was studied. Hydroxypropyl methylcellulose(HPMC), such as dextran T‐500 and gelatin G‐9382, polyisoprene (PI), and acrylonitrile/butadiene copolymer (NBR) were used as substra...
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| Published in: | Scanning Vol. 35; no. 4; pp. 213 - 221 |
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Blackwell Publishing Ltd
01-07-2013
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In this article, morphology of progesterone polymorphs prepared by polymer‐induced heteronucleation (PIHn) technique was studied. Hydroxypropyl methylcellulose(HPMC), such as dextran T‐500 and gelatin G‐9382, polyisoprene (PI), and acrylonitrile/butadiene copolymer (NBR) were used as substrates. The crystallizations were performed by solvent evaporation at room temperature from 0.5, 10, and 40 mg/ml solutions in chloroform and acetone. Progesterone polymorphs were identified by X‐ray diffraction. Differential scanning calorimetry and total attenuated reflectance infrared spectroscopy were used as complementary techniques in the identification. Depending on the polymeric matrix and the concentration used, form 1, form 2, or mixture of both polymorphs were obtained. Scanning electron microscopy pictures evidenced difference in morphology and in homogeneity of the two progesterone polymorphs. These polymorphs prepared by PIHn, did not present a distinctive morphology that allows identifying polymorph by its crystal habit. Hence, polymeric matrix induced the crystallization, affecting polymorphism and morphology. SCANNING 35:213‐221, 2013. © 2012 Wiley Periodicals, Inc. |
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| AbstractList | In this article, morphology of progesterone polymorphs prepared by polymer-induced heteronucleation (PIHn) technique was studied. Hydroxypropyl methylcellulose(HPMC), such as dextran T-500 and gelatin G-9382, polyisoprene (PI), and acrylonitrile/butadiene copolymer (NBR) were used as substrates. The crystallizations were performed by solvent evaporation at room temperature from 0.5, 10, and 40 mg/ml solutions in chloroform and acetone. Progesterone polymorphs were identified by X-ray diffraction. Differential scanning calorimetry and total attenuated reflectance infrared spectroscopy were used as complementary techniques in the identification. Depending on the polymeric matrix and the concentration used, form 1, form 2, or mixture of both polymorphs were obtained. Scanning electron microscopy pictures evidenced difference in morphology and in homogeneity of the two progesterone polymorphs. These polymorphs prepared by PIHn, did not present a distinctive morphology that allows identifying polymorph by its crystal habit. Hence, polymeric matrix induced the crystallization, affecting polymorphism and morphology. Summary In this article, morphology of progesterone polymorphs prepared by polymer‐induced heteronucleation (PIHn) technique was studied. Hydroxypropyl methylcellulose(HPMC), such as dextran T‐500 and gelatin G‐9382, polyisoprene (PI), and acrylonitrile/butadiene copolymer (NBR) were used as substrates. The crystallizations were performed by solvent evaporation at room temperature from 0.5, 10, and 40 mg/ml solutions in chloroform and acetone. Progesterone polymorphs were identified by X‐ray diffraction. Differential scanning calorimetry and total attenuated reflectance infrared spectroscopy were used as complementary techniques in the identification. Depending on the polymeric matrix and the concentration used, form 1, form 2, or mixture of both polymorphs were obtained. Scanning electron microscopy pictures evidenced difference in morphology and in homogeneity of the two progesterone polymorphs. These polymorphs prepared by PIHn, did not present a distinctive morphology that allows identifying polymorph by its crystal habit. Hence, polymeric matrix induced the crystallization, affecting polymorphism and morphology. SCANNING 35:213‐221, 2013. © 2012 Wiley Periodicals, Inc. In this article, morphology of progesterone polymorphs prepared by polymer‐induced heteronucleation (PIHn) technique was studied. Hydroxypropyl methylcellulose(HPMC), such as dextran T‐500 and gelatin G‐9382, polyisoprene (PI), and acrylonitrile/butadiene copolymer (NBR) were used as substrates. The crystallizations were performed by solvent evaporation at room temperature from 0.5, 10, and 40 mg/ml solutions in chloroform and acetone. Progesterone polymorphs were identified by X‐ray diffraction. Differential scanning calorimetry and total attenuated reflectance infrared spectroscopy were used as complementary techniques in the identification. Depending on the polymeric matrix and the concentration used, form 1, form 2, or mixture of both polymorphs were obtained. Scanning electron microscopy pictures evidenced difference in morphology and in homogeneity of the two progesterone polymorphs. These polymorphs prepared by PIHn, did not present a distinctive morphology that allows identifying polymorph by its crystal habit. Hence, polymeric matrix induced the crystallization, affecting polymorphism and morphology. SCANNING 35:213‐221, 2013. © 2012 Wiley Periodicals, Inc. Summary In this article, morphology of progesterone polymorphs prepared by polymer-induced heteronucleation (PIHn) technique was studied. Hydroxypropyl methylcellulose(HPMC), such as dextran T-500 and gelatin G-9382, polyisoprene (PI), and acrylonitrile/butadiene copolymer (NBR) were used as substrates. The crystallizations were performed by solvent evaporation at room temperature from 0.5, 10, and 40 mg/ml solutions in chloroform and acetone. Progesterone polymorphs were identified by X-ray diffraction. Differential scanning calorimetry and total attenuated reflectance infrared spectroscopy were used as complementary techniques in the identification. Depending on the polymeric matrix and the concentration used, form 1, form 2, or mixture of both polymorphs were obtained. Scanning electron microscopy pictures evidenced difference in morphology and in homogeneity of the two progesterone polymorphs. These polymorphs prepared by PIHn, did not present a distinctive morphology that allows identifying polymorph by its crystal habit. Hence, polymeric matrix induced the crystallization, affecting polymorphism and morphology. SCANNING 35:213-221, 2013. © 2012 Wiley Periodicals, Inc. [PUBLICATION ABSTRACT] Summary In this article, morphology of progesterone polymorphs prepared by polymer-induced heteronucleation (PIHn) technique was studied. Hydroxypropyl methylcellulose(HPMC), such as dextran T-500 and gelatin G-9382, polyisoprene (PI), and acrylonitrile/butadiene copolymer (NBR) were used as substrates. The crystallizations were performed by solvent evaporation at room temperature from 0.5, 10, and 40 mg/ml solutions in chloroform and acetone. Progesterone polymorphs were identified by X-ray diffraction. Differential scanning calorimetry and total attenuated reflectance infrared spectroscopy were used as complementary techniques in the identification. Depending on the polymeric matrix and the concentration used, form 1, form 2, or mixture of both polymorphs were obtained. Scanning electron microscopy pictures evidenced difference in morphology and in homogeneity of the two progesterone polymorphs. These polymorphs prepared by PIHn, did not present a distinctive morphology that allows identifying polymorph by its crystal habit. Hence, polymeric matrix induced the crystallization, affecting polymorphism and morphology. SCANNING 35:213-221, 2013. [copy 2012 Wiley Periodicals, Inc. |
| Author | Campos, Carlos E. M. Soldi, Valdir Cardoso, Simone G. Araya-Sibaja, Andrea M. A. Cuffini, Silvia L. Fandaruff, Cinira |
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| Cites_doi | 10.1021/ja042561m 10.1205/cherd06234 10.1016/S0378-5173(98)00348-2 10.1016/S0169-409X(97)00089-6 10.1021/ja0286526 10.1016/j.anireprosci.2007.09.005 10.1016/S0169-409X(01)00097-7 10.1211/jpp.59.1.0005 10.1016/j.ijpharm.2009.08.015 10.1208/s12249-010-9508-7 10.1002/jps.20983 10.1080/10837450802310180 |
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| Keywords | crystalline drugs polymorphism morphology polymer-induced heteronucleation progesterone |
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| References_xml | – volume: 124 start-page: 14834 year: 2002 end-page: 14835 article-title: The use of polymer heteronuclei for crystalline polymorph selection publication-title: J Am Chem Soc – volume: 127 start-page: 5512 year: 2005 end-page: 5517 article-title: Crystalline polymorph selection and discovery with polymer heteronuclei publication-title: J Am ChemSoc – start-page: 77 year: 1999 end-page: 78 – volume: 96 start-page: 3419 year: 2007 end-page: 3431 article-title: The polymorphism of progesterone: stabilization of a “disappearing” polymorph by co‐crystallization publication-title: J Pharm Sci – volume: 13 start-page: 559 year: 2008 end-page: 568 article-title: Spherical crystallization of mebendazole to improve processability publication-title: Pharm Dev Technol – volume: 85 start-page: 893 year: 2007 end-page: 905 article-title: Recent advances in crystallization control: an industrial perspective publication-title: Chem Eng Res Des – volume: 48 start-page: 3 year: 2001 end-page: 26 article-title: Crystalline solids publication-title: Adv Drug Deliver Rev – volume: 59 start-page: 29 year: 2007 end-page: 39 article-title: Modification of the crystal habit of celecoxib for improved processability publication-title: J Pharm Pharmacol – volume: 28 start-page: 363 year: 1997 end-page: 392 article-title: Conceptual and commercially available intravaginal veterinary drug delivery systems publication-title: Adv Drug Deliver Rev – volume: 11 start-page: 1493 year: 2010 end-page: 1498 article-title: Study of polymorphs of progesterone by novel melt sonocrystallization technique: a technical note publication-title: AAPS Pharm Sci Tech – volume: 108 start-page: 356 year: 2008 end-page: 363 article-title: Room temperature vulcanizing silicone sheaths on a reusable support for progesterone delivery in estrous synchronization treatments in cattle publication-title: Anim Reprod Sci – volume: 382 start-page: 98 year: 2009 end-page: 103 article-title: Polyisoprene matrix for progesterone release: in vitro and in vivo studies publication-title: Int J Pharmaceut – volume: 177 start-page: 231 year: 1999 end-page: 245 article-title: Examples of successful crystal structure prediction: polymorphs of primidone and progesterone publication-title: Int J Pharmaceut – ident: e_1_2_6_10_1 doi: 10.1021/ja042561m – ident: e_1_2_6_14_1 doi: 10.1205/cherd06234 – ident: e_1_2_6_9_1 doi: 10.1016/S0378-5173(98)00348-2 – ident: e_1_2_6_11_1 doi: 10.1016/S0169-409X(97)00089-6 – ident: e_1_2_6_8_1 doi: 10.1021/ja0286526 – ident: e_1_2_6_4_1 doi: 10.1016/j.anireprosci.2007.09.005 – ident: e_1_2_6_13_1 doi: 10.1016/S0169-409X(01)00097-7 – ident: e_1_2_6_2_1 doi: 10.1211/jpp.59.1.0005 – ident: e_1_2_6_5_1 doi: 10.1016/j.ijpharm.2009.08.015 – ident: e_1_2_6_12_1 doi: 10.1208/s12249-010-9508-7 – start-page: 77 volume-title: Solid‐state chemistry of drugs year: 1999 ident: e_1_2_6_3_1 contributor: fullname: Byrn S – ident: e_1_2_6_7_1 doi: 10.1002/jps.20983 – ident: e_1_2_6_6_1 doi: 10.1080/10837450802310180 |
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In this article, morphology of progesterone polymorphs prepared by polymer‐induced heteronucleation (PIHn) technique was studied. Hydroxypropyl... In this article, morphology of progesterone polymorphs prepared by polymer-induced heteronucleation (PIHn) technique was studied. Hydroxypropyl... In this article, morphology of progesterone polymorphs prepared by polymer‐induced heteronucleation (PIHn) technique was studied. Hydroxypropyl... Summary In this article, morphology of progesterone polymorphs prepared by polymer-induced heteronucleation (PIHn) technique was studied. Hydroxypropyl... |
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| SubjectTerms | Butadiene Calorimetry, Differential Scanning crystalline drugs Crystallization Habits Homogeneity Microscopy, Electron, Scanning Morphology Polyisoprenes polymer-induced heteronucleation Polymers - chemistry polymorphism progesterone Progesterone - chemistry Reproduction Scanning Spectrum Analysis X-Ray Diffraction |
| Title | Morphology study of progesterone polymorphs prepared by polymer-induced heteronucleation (PIHn) |
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