Morphology study of progesterone polymorphs prepared by polymer-induced heteronucleation (PIHn)

• Published in: Scanning Vol. 35; no. 4; pp. 213 - 221
• Main Authors: Araya-Sibaja, Andrea M. A., Fandaruff, Cinira, Campos, Carlos E. M., Soldi, Valdir, Cardoso, Simone G., Cuffini, Silvia L.
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01-07-2013; Hindawi Limited
• Subjects: Butadiene; Calorimetry, Differential Scanning; crystalline drugs; Crystallization; Habits; Homogeneity; Microscopy, Electron, Scanning; Morphology; Polyisoprenes; polymer-induced heteronucleation; Polymers - chemistry; polymorphism; progesterone; Progesterone - chemistry; Reproduction; Scanning; Spectrum Analysis; X-Ray Diffraction; crystalline drugs; polymorphism; morphology; polymer-induced heteronucleation; progesterone
• ISSN: 0161-0457; 1932-8745
• DOI: 10.1002/sca.21045

Summary
In this article, morphology of progesterone polymorphs prepared by polymer‐induced heteronucleation (PIHn) technique was studied. Hydroxypropyl methylcellulose(HPMC), such as dextran T‐500 and gelatin G‐9382, polyisoprene (PI), and acrylonitrile/butadiene copolymer (NBR) were used as substrates. The crystallizations were performed by solvent evaporation at room temperature from 0.5, 10, and 40 mg/ml solutions in chloroform and acetone. Progesterone polymorphs were identified by X‐ray diffraction. Differential scanning calorimetry and total attenuated reflectance infrared spectroscopy were used as complementary techniques in the identification. Depending on the polymeric matrix and the concentration used, form 1, form 2, or mixture of both polymorphs were obtained. Scanning electron microscopy pictures evidenced difference in morphology and in homogeneity of the two progesterone polymorphs. These polymorphs prepared by PIHn, did not present a distinctive morphology that allows identifying polymorph by its crystal habit. Hence, polymeric matrix induced the crystallization, affecting polymorphism and morphology. SCANNING 35:213‐221, 2013. © 2012 Wiley Periodicals, Inc.