causal role of breakfast in energy balance and health: a randomized controlled trial in lean adults

• Published in: The American journal of clinical nutrition Vol. 100; no. 2; pp. 539 - 547
• Main Authors: Betts, James A, Richardson, Judith D, Chowdhury, Enhad A, Holman, Geoffrey D, Tsintzas, Kostas, Thompson, Dylan
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Nutrition 01-08-2014; American Society for Clinical Nutrition, Inc
• Subjects: adipose tissue; adiposity; Adult; Adults; appetite; Appetite Regulation; Bioenergetics; Biomarkers - blood; blood glucose; Blood Glucose - analysis; Breakfast; Breakfast foods; clinical nutrition; Clinical trials; Cohort Studies; Diet; Energy Intake; Energy Metabolism; fasting; Feeding Behavior; Female; Follow-Up Studies; glucose; Health Promotion; heat production; hematology; Humans; Hyperglycemia - blood; Hyperglycemia - prevention & control; Male; men; metabolism; Middle Aged; middle-aged adults; Motor Activity; physical activity; randomized clinical trials; resting metabolic rate; Thermogenesis; Up-Regulation; women; X-radiation; Young Adult; young adults; England; United Kingdom > UK
• ISSN: 0002-9165; 1938-3207
• DOI: 10.3945/ajcn.114.083402

Background: Popular beliefs that breakfast is the most important meal of the day are grounded in cross-sectional observations that link breakfast to health, the causal nature of which remains to be explored under real-life conditions.Objective: The aim was to conduct a randomized controlled trial examining causal links between breakfast habits and all components of energy balance in free-living humans.Design: The Bath Breakfast Project is a randomized controlled trial with repeated-measures at baseline and follow-up in a cohort in southwest England aged 21–60 y with dual-energy X-ray absorptiometry–derived fat mass indexes ≤11 kg/m2 in women (n = 21) and ≤7.5 kg/m2 in men (n = 12). Components of energy balance (resting metabolic rate, physical activity thermogenesis, energy intake) and 24-h glycemic responses were measured under free-living conditions with random allocation to daily breakfast (≥700 kcal before 1100) or extended fasting (0 kcal until 1200) for 6 wk, with baseline and follow-up measures of health markers (eg, hematology/biopsies).Results: Contrary to popular belief, there was no metabolic adaptation to breakfast (eg, resting metabolic rate stable within 11 kcal/d), with limited subsequent suppression of appetite (energy intake remained 539 kcal/d greater than after fasting; 95% CI: 157, 920 kcal/d). Rather, physical activity thermogenesis was markedly higher with breakfast than with fasting (442 kcal/d; 95% CI: 34, 851 kcal/d). Body mass and adiposity did not differ between treatments at baseline or follow-up and neither did adipose tissue glucose uptake or systemic indexes of cardiovascular health. Continuously measured glycemia was more variable during the afternoon and evening with fasting than with breakfast by the final week of the intervention (CV: 3.9%; 95% CI: 0.1%, 7.8%).Conclusions: Daily breakfast is causally linked to higher physical activity thermogenesis in lean adults, with greater overall dietary energy intake but no change in resting metabolism. Cardiovascular health indexes were unaffected by either of the treatments, but breakfast maintained more stable afternoon and evening glycemia than did fasting. This trial was registered at www.isrctn.org as ISRCTN31521726.