A mathematical model describing the thermal virus inactivation

• Published in: Vaccine Vol. 19; no. 25; pp. 3575 - 3582
• Main Authors: Noël, Catherine, Charles, Sandrine, Françon, Alain, Flandrois, Jean Pierre
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 14-05-2001; Elsevier
• Subjects: Bacteriology; Biological and medical sciences; Drug Stability; Drug Storage; Fundamental and applied biological sciences. Psychology; Humans; In Vitro Techniques; Kinetic; Life Sciences; Mathematical model; Microbiology; Models, Biological; Models, Theoretical; Oral polymyelitis vaccine; Other; poliovirus; Poliovirus Vaccine, Oral - antagonists & inhibitors; Poliovirus Vaccine, Oral - chemistry; Temperature; Thermal inactivation; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies; Viral vaccines; Viral Vaccines - antagonists & inhibitors; Viral Vaccines - chemistry; Virology; Temperature; Oral polymyelitis vaccine; Viral vaccines; Kinetic; Mathematical model; Thermal inactivation; Virus
• ISSN: 0264-410X; 1873-2518; 0264-410X
• DOI: 10.1016/S0264-410X(01)00011-1

A new mathematical model is proposed to describe the inactivation of viruses at different temperatures. This model takes into account the exponential decrease of the viral titer with time, the inactivation rate being an exponential function of the temperature. A one-step non-linear regression was used to fit oral poliovirus vaccine (OPV) experimental data. In one of the applications of the model, we illustrate the use of our model to compare the accelerated degradation test of OPV new formulations to standard OPV. Such a model is both simple and convenient to use. It should be a useful tool in optimizing formulations for live viral vaccines.