SnapShot: Jak-STAT Signaling II

The JAK-STAT pathway is an evolutionarily conserved signal transduction paradigm, providing mechanisms for rapid receptor-to-nucleus communication and transcription control. Discoveries in this field provided insights into primary immunodeficiencies, inherited autoimmune and autoinflammatory disease...

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Bibliographic Details
Published in:	Cell Vol. 181; no. 7; pp. 1696 - 1696.e1
Main Authors:	Villarino, Alejandro V., Gadina, Massimo, O’Shea, John J., Kanno, Yuka
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 25-06-2020
Subjects:	Animals Cell Membrane - metabolism Cell Nucleus - metabolism Gene Expression Regulation - genetics Gene Expression Regulation - physiology Humans Janus Kinases - genetics Janus Kinases - metabolism Janus Kinases - physiology Signal Transduction - physiology STAT Transcription Factors - genetics STAT Transcription Factors - metabolism STAT Transcription Factors - physiology
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Summary:	The JAK-STAT pathway is an evolutionarily conserved signal transduction paradigm, providing mechanisms for rapid receptor-to-nucleus communication and transcription control. Discoveries in this field provided insights into primary immunodeficiencies, inherited autoimmune and autoinflammatory diseases, and hematologic and oncologic disorders, giving rise to a new class of drugs, JAK inhibitors (or Jakinibs).
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0092-8674 1097-4172 1097-4172
DOI:	10.1016/j.cell.2020.04.052