Preparation and evaluation of carboplatin biodegradable polymeric nanoparticles

• Published in: International journal of pharmaceutics Vol. 385; no. 1; pp. 176 - 180
• Main Authors: Nanjwade, Basavaraj K., Singh, Jeet, Parikh, Kemy A., Manvi, F.V.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 29-01-2010; Elsevier
• Subjects: Alginates - chemistry; Animals; Antineoplastic Agents - administration & dosage; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacokinetics; Biodegradable; Biological and medical sciences; Calcium Chloride - chemistry; Carboplatin; Carboplatin - administration & dosage; Carboplatin - chemistry; Carboplatin - pharmacokinetics; Chemistry, Pharmaceutical; Chitosan - chemistry; Cross-Linking Reagents - chemistry; Drug Carriers; Drug Compounding; Drug Stability; General pharmacology; Glucuronic Acid - chemistry; Hexuronic Acids - chemistry; Injections, Intravenous; Ion gelification; Medical sciences; Mice; Nanoparticles; Particle Size; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Polylysine - chemistry; Solubility; Surface Properties; Targeting; Technology, Pharmaceutical - methods; Tissue Distribution; Nanoparticles; Carboplatin; Biodegradable; Targeting; Ion gelification; Antineoplastic agent; Evaluation; Pharmaceutical technology; Biodegradability; Nanoparticle; Ions; Polymer; Target; Preparation; Microparticle; Platinum II Complexes
• ISSN: 0378-5173; 1873-3476
• DOI: 10.1016/j.ijpharm.2009.10.030

The present study was designed to evaluate targeting efficiency of carboplatin anticancer drug. Drug was encapsulated in natural biodegradable polymer sodium alginate. The nanoparticles were prepared by the ion gelification technique and evaluated for encapsulation efficiency, loading capacity,
in vitro release pattern and targeting efficiency. Drug encapsulation efficiency was about 52.24–68.70% for different formulations. In vitro release profile showed duration of drug release was also increased (more than 12
h) by nanoparticulate formulation as compared to pure drug (up to 3
h). The formulations were parenterally administered to laca mice and the drug was detected in body organs like liver, lungs and spleen. In case of free drug, less amount of drug was found in liver, lungs and spleen as compared to drug encapsulated nanoparticles. Thus sodium alginate nanoparticles can be used for targeting carboplatin and it can be a promising tool in the delivery of anticancer drugs.