Low Levels of Antiretroviral-Resistant HIV Infection in a Routine Clinic in Cameroon that Uses the World Health Organization (WHO) Public Health Approach to Monitor Antiretroviral Treatment and Adequacy with the WHO Recommendation for Second-Line Treatment

• Published in: Clinical infectious diseases Vol. 48; no. 9; pp. 1318 - 1322
• Main Authors: Kouanfack, Charles, Montavon, Celine, Laurent, Christian, Aghokeng, Avelin, Kenfack, Alain, Bourgeois, Anke, Koulla-Shiro, Sinata, Mpoudi-Ngole, Eitel, Peeters, Martine, Delaporte, Eric
• Format: Journal Article
• Language: English
• Published: Oxford The University of Chicago Press 01-05-2009; University of Chicago Press; Oxford University Press
• Subjects: Adult; Anti-HIV Agents - pharmacology; Anti-HIV Agents - therapeutic use; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiretrovirals; Antiviral agents; Arts; Biological and medical sciences; Cameroon; Cross-Sectional Studies; Drug resistance; Drug Resistance, Viral; Female; Genetic mutation; Guideline Adherence; HIV; HIV - drug effects; HIV - isolation & purification; HIV 1; HIV infections; HIV Infections - drug therapy; HIV Infections - virology; HIV/AIDS; Human immunodeficiency virus; Human viral diseases; Humans; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Infectious diseases; Male; Medical sciences; Middle Aged; Pharmacology. Drug treatments; Public health; Treatment Outcome; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Viral load; Virology; World; Cameroon; Africa; Infection; Immunopathology; Antiretroviral agent; Treatment; Viral disease; Public health organization; Antiviral; AIDS; Immune deficiency; Recommendation; Public health
• ISSN: 1058-4838; 1537-6591
• DOI: 10.1086/597779

A cross-sectional study, performed at a routine human immunodeficiency virus (HIV)/AIDS clinic in Cameroon that uses the World Health Organization public health approach, showed low rates of virological failure and drug resistance at 12 and 24 months after initiation of antiretroviral therapy. Importantly, the cross-sectional study also showed that the World Health Organization recommendation for second-line treatment would be effective in almost all patients with HIV drug resistance mutations.