The spatiotemporal dynamics of semantic integration in the human brain

• Published in: Nature communications Vol. 14; no. 1; pp. 6336 - 13
• Main Authors: Murphy, Elliot, Forseth, Kiefer J., Donos, Cristian, Snyder, Kathryn M., Rollo, Patrick S., Tandon, Nitin
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 24-10-2023; Nature Publishing Group; Nature Portfolio
• Subjects: 631/378/2649/1594; 631/378/2649/1773; Brain; Brain - physiology; Brain Mapping - methods; Broadband; Cortex (frontal); Cortex (parietal); Epilepsy; Hemispheric laterality; Humanities and Social Sciences; Humans; Integration; Language; Magnetic Resonance Imaging - methods; Mosaics; multidisciplinary; Science; Science (multidisciplinary); Semantics; Sentences; Superior temporal sulcus; Temporal gyrus; Temporal lobe; Temporal Lobe - physiology; Words (language)
• ISSN: 2041-1723; 2041-1723
• DOI: 10.1038/s41467-023-42087-8

Language depends critically on the integration of lexical information across multiple words to derive semantic concepts. Limitations of spatiotemporal resolution have previously rendered it difficult to isolate processes involved in semantic integration. We utilized intracranial recordings in epilepsy patients (n = 58) who read written word definitions. Descriptions were either referential or non-referential to a common object. Semantically referential sentences enabled high frequency broadband gamma activation (70–150 Hz) of the inferior frontal sulcus (IFS), medial parietal cortex, orbitofrontal cortex (OFC) and medial temporal lobe in the left, language-dominant hemisphere. IFS, OFC and posterior middle temporal gyrus activity was modulated by the semantic coherence of non-referential sentences, exposing semantic effects that were independent of task-based referential status. Components of this network, alongside posterior superior temporal sulcus, were engaged for referential sentences that did not clearly reduce the lexical search space by the final word. These results indicate the existence of complementary cortical mosaics for semantic integration in posterior temporal and inferior frontal cortex.
Limitations of spatiotemporal resolution have rendered it difficult to isolate language. Here, intracranial recordings were used to map semantic processes pertaining to sentence integration, unveiling complementary roles for frontotemporal brain regions.