Polymorphism of butyrophenones related to haloperidol

Polymorphism of butyrophenones related to haloperidol

A comparison of X-ray powder diffraction patterns, IR spectra, and crystal structures of structurally related compounds belonging to the butyrophenone family has been undertaken to obtain information about the elements of chemical structure which predispose a substance to exhibit polymorphism. Five...

Full description

Saved in:
Bibliographic Details
Published in:Journal of pharmaceutical sciences Vol. 73; no. 4; p. 512
Main Authors: Azibi, M, Draguet-Brughmans, M, Bouche, R
Format: Journal Article
Language:English
Published: United States 01-04-1984
Subjects:
Butyrophenones
Calorimetry, Differential Scanning
Chemical Phenomena
Chemistry, Physical
Crystallization
Haloperidol - analogs & derivatives
Spectrophotometry, Infrared
Thermodynamics
X-Ray Diffraction
Online Access:Get more information
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A comparison of X-ray powder diffraction patterns, IR spectra, and crystal structures of structurally related compounds belonging to the butyrophenone family has been undertaken to obtain information about the elements of chemical structure which predispose a substance to exhibit polymorphism. Five butyrophenones, differing by the nature of only one substituent, were selected. After crystallization from 15 solvents, it appears that two compounds of the group exhibit more than one crystalline form. An explanation of the absence of polymorphism in the other compounds of the group is proposed and discussed.
ISSN:0022-3549
DOI:10.1002/jps.2600730420