Memory engram storage and retrieval

Highlights • We review the history of research into putative memory storage mechanisms. • We highlight recent advances catalyzed by memory engram labeling technology. • We discuss the physiological properties of engram cells in memory consolidation. • We describe a novel investigation into the natur...

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Bibliographic Details
Published in:	Current opinion in neurobiology Vol. 35; pp. 101 - 109
Main Authors:	Tonegawa, Susumu, Pignatelli, Michele, Roy, Dheeraj S, Ryan, Tomás J
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-12-2015
Subjects:	Amnesia, Retrograde - metabolism Amnesia, Retrograde - physiopathology Animals Genes, Immediate-Early - genetics Genes, Immediate-Early - physiology Humans Memory - physiology Mental Recall - physiology Nerve Net - physiology Neurology Neuronal Plasticity - physiology Neurons - metabolism Neurons - physiology Optogenetics - methods Psychiatry
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Summary:	Highlights • We review the history of research into putative memory storage mechanisms. • We highlight recent advances catalyzed by memory engram labeling technology. • We discuss the physiological properties of engram cells in memory consolidation. • We describe a novel investigation into the nature of retrograde amnesia. • We propose a differentiation between the mechanism of memory storage and retrieval.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0959-4388 1873-6882
DOI:	10.1016/j.conb.2015.07.009