Diffusion of Vanadium Ions in Artificial Saliva and Its Elimination from the Oral Cavity by Pharmacological Compounds Present in Mouthwashes

• Published in: Biomolecules (Basel, Switzerland) Vol. 12; no. 7; p. 947
• Main Authors: Fangaia, Sónia I. G., Cabral, Ana M. T. D. P. V., Nicolau, Pedro M. G., Guerra, Fernando A. D. R. A., Rodrigo, M. Melia, Ribeiro, Ana C. F., Valente, Artur J. M., Esteso, Miguel A.
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 06-07-2022; MDPI
• Subjects: Ammonium; Biocompatibility; Chemical elements; cyclodextrins; Diffusion; Electrolytes; Fluorides; Hyaluronic acid; ion release; mouthwashes; Oral cavity; Prostheses; Saliva; SDS; Sodium; Sodium fluoride; Sodium hyaluronate; Sodium lauryl sulfate; Transplants & implants; Vanadate; Vanadium; β-Cyclodextrin; Germany
• ISSN: 2218-273X; 2218-273X
• DOI: 10.3390/biom12070947

In this study, diffusion coefficients of ammonium vanadate at tracer concentrations in artificial saliva with and without sodium fluoride, at different pH values, were measured using an experimental model based on the Taylor dispersion technique. Ternary mutual diffusion coefficients (D11, D22, D12, and D21) for four aqueous systems {NH4VO3 (component 1) + β-cyclodextrin (β-CD) (component 2),} {NH4VO3 (component 1) + β-cyclodextrin (HP-β-CD) (component 2)}, {NH4VO3 (component 1) + sodium dodecyl sulphate (SDS) (component 2)} and {NH4VO3 (component 1) + sodium hyaluronate (NaHy) (component 2)} at 25.00 °C were also measured by using the same technique. These data showed that diffusion of ammonium vanadate was strongly affected in all aqueous media studied. Furthermore, a significant coupled diffusion of this salt and β-CD was observed through the non-zero values of the cross-diffusion coefficients, D12, allowing us to conclude that there is a strong interaction between these two components. This finding is very promising considering the removal, from the oral cavity, of vanadium resulting from tribocorrosion of Ti-6Al-4V prosthetic devices.