Pharmacogenomics and Pharmacogenetics: In Silico Prediction of Drug Effects in Treatments for Novel Coronavirus SARS-CoV2 Disease

• Published in: Pharmacogenomics and personalized medicine Vol. 13; pp. 463 - 484
• Main Authors: Cafiero, Concetta, Re, Agnese, Micera, Alessandra, Palmirotta, Raffaele, Monaco, Delio, Romano, Francesca, Fabrizio, Claudia, Di Francia, Raffaele, Cacciamani, Andrea, Surico, Pier Luigi, D'Amato, Gerardo, Pisconti, Salvatore
• Format: Journal Article
• Language: English
• Published: Macclesfield Taylor & Francis Ltd 01-01-2020; Dove; Dove Medical Press
• Subjects: adr; Clinical trials; Coronaviruses; COVID-19; Cytokines; Disease transmission; Drug dosages; drug effects; Drug therapy; Evolution; FDA approval; Genetic analysis; Genetic diversity; Genomes; in-silico; Infections; Literature reviews; Lymphocytes; Metabolism; Pandemics; Pharmacogenetics; Pharmacogenomics; Pneumonia; Polymorphism; Precision medicine; Review; RNA polymerase; sars-cov2; Serology; Severe acute respiratory syndrome coronavirus 2; Single-nucleotide polymorphism; Therapeutic targets; Viruses
• ISSN: 1178-7066; 1178-7066
• DOI: 10.2147/PGPM.S270069

The latest developments in precision medicine allow the modulation of therapeutic approaches in different pathologies on the basis of the specific molecular characterization of the patient. This review of the literature coupled with in silico analysis was to provide a selected screening of interactions between single-nucleotide polymorphisms (SNPs) and drugs (repurposed, investigational, and biological agents) showing efficacy and toxicityin counteracting Covid-19 infection. In silico analysis of genetic variants related to each drug was performed on such databases as PharmGKB, Ensembl Genome Browser, www.drugs.com, and SNPedia, with an extensive literature review of papers (to May 10, 2020) on Covid-19 treatments using Medline, Embase, International Pharmaceutical Abstracts, PharmGKB, and Google Scholar. The clinical relevance of SNPs, known as both drug targets and markers, considering genetic variations with known drug responses, and the therapeutic consequences are discussed. In the context of clinical treatment of Covid-19, including infection prevention, control measures, and supportive care, this review highlights the importance of a personalized approach in the final selection of therapy, which is probably essential in the management of the Covid-19 pandemic.