Successful treatment of lower urinary tract infections with oral fosfomycin: a report of three cases

• Published in: Revista da Sociedade Brasileira de Medicina Tropical Vol. 48; no. 3; pp. 358 - 360
• Main Authors: da Silva, Juliana Oliveira, Yu, Maria Cecilia Zorat, Doi, André, de Araujo, Maria Rita Elmor, Neto, Pedro Aurélio Mathiasi, Furtado, Guilherme Henrique Campos
• Format: Journal Article
• Language: English
• Published: Brazil Sociedade Brasileira de Medicina Tropical - SBMT 01-06-2015; Sociedade Brasileira de Medicina Tropical (SBMT)
• Subjects: Aged; Aged, 80 and over; Anti-Bacterial Agents - therapeutic use; beta-Lactamases - secretion; Disk Diffusion Antimicrobial Tests; Female; Fosfomycin; Fosfomycin - therapeutic use; Humans; Klebsiella Infections - drug therapy; Klebsiella Infections - microbiology; Klebsiella pneumoniae - drug effects; Klebsiella pneumoniae - enzymology; KPC-producing Klebsiella pneumoniae; Male; Middle Aged; Treatment Outcome; TROPICAL MEDICINE; Urinary tract infection treatment; Urinary Tract Infections - drug therapy; Urinary Tract Infections - microbiology; Urinary tract infection treatment; KPC-producing Klebsiella pneumoniae; Fosfomycin
• ISSN: 0037-8682; 1678-9849; 1678-9849; 0037-8682
• DOI: 10.1590/0037-8682-0289-2014

Infections due to multidrug-resistant organisms continue to increase, and therapeutic options remain scarce. Given this challenge, it has become necessary to use older antimicrobials for treatment of these pathogens. We report three patients with lower urinary tract infections caused by Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae who were successfully treated with a seven-day course of oral fosfomycin monotherapy.