Effect of Antidepressants on Immunological Reactivity in ASC Mice with Genetically Determined Depression-Like State

• Published in: Bulletin of experimental biology and medicine Vol. 161; no. 2; pp. 266 - 269
• Main Authors: Gevorgyan, M. M., Idova, G. V., Al’perina, E. L., Tikhonova, M. A., Kulikov, A. V.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01-06-2016; Springer; Springer Nature B.V
• Subjects: Adjuvants, Immunologic - pharmacology; Animals; Antibodies; Antidepressive Agents - pharmacology; Antigen-Presenting Cells - drug effects; Antigen-Presenting Cells - immunology; Biomedical and Life Sciences; Biomedicine; Cell Biology; Depression (Mood disorder); Depression - drug therapy; Depression - genetics; Depression - immunology; Drug Evaluation, Preclinical; Fluoxetine; Fluoxetine - pharmacology; Genetic Predisposition to Disease; Imipramine; Immune response; Internal Medicine; Laboratory Medicine; Lymphocyte Count; Male; Mice, Inbred CBA; Microbiology; Microbiology and Immunology; Parenting; Pathology; Serotonin Uptake Inhibitors - pharmacology; Spleen - drug effects; Spleen - immunology; Spleen - pathology; T cells; antidepressants; fluoxetine; T cell Subpopulations; IgM antibody-producing cells; imipramine
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-016-3392-4

The effect of chronic treatment with antidepressant drugs fluoxetine (20 mg/kg) and imipramine (25 mg/kg) on the number of antibody-producing cells and the main T cell subpopulations in ASC mice characterized by genetic predisposition to depression-like states was studied at the peak of the SE-induced immune response (5×10
8
). Fluoxetine produced an immunostimulatory effect manifested in an increase in the relative and absolute number of IgM antibody-producing cells in the spleen and index of immunoreactivity (CD4/CD8). Administration of fl uoxetine to parental mouse strains without depression (CBA and AKR) had no effect (CBA) or reduced the immune response. The CD4/CD8 ratio did not increase under these conditions. Imipramine was ineffective in the correction of immune reactions in a depression-like state.