Amlodipine-gold Nanoparticles as a New “Turn off-on’’ Sensor for the Sensitive Determination of Methimazole

• Published in: Journal of analytical chemistry (New York, N.Y.) Vol. 75; no. 3; pp. 402 - 408
• Main Authors: Jafar Abolhasani, Samadi, Azam, Vahabzadeh, Masoumeh Haji
• Format: Journal Article
• Language: English
• Published: Moscow Pleiades Publishing 01-03-2020; Springer; Springer Nature B.V
• Subjects: Amlodipine; Analytical Chemistry; Blood plasma; Care and treatment; Chemistry; Chemistry and Materials Science; Energy transfer; Fluorescence; Gold; Methimazole; Nanoparticles; Physiological aspects; Plasma; Sensors; Thyroid diseases; Thyroid gland; Thyroid hormones; Iran; thiamazole; gold nanoparticles; turn-off-on sensor; fluorescence quenching; fluorescence resonance energy transfer; methimazole; amlodipine
• ISSN: 1061-9348; 1608-3199
• DOI: 10.1134/S1061934820030028

We present a new and sensitive fluorescent nanosensor for the direct determination of methimazole (
MML
) in human plasma samples. The strategy is based on fluorescence resonance energy transfer between amlodipine, an inexpensive pharmaceutical compound, as an energy donor and gold nanoparticles as an energy acceptor. The recovered fluorescence intensity in the presence of MML allows a direct and rapid quantitation of MML in human plasma samples with a detection limit of 0.15 ng/mL.