Polyphenols and Their Nanoformulations: Protective Effects against Human Diseases

• Published in: Life (Basel, Switzerland) Vol. 12; no. 10; p. 1639
• Main Authors: Anand, Santosh, Sowbhagya, Ramachandregowda, Ansari, Mohammad Azam, Alzohairy, Mohammad A., Alomary, Mohammad N., Almalik, Asiyah I., Ahmad, Wasim, Tripathi, Takshashila, Elderdery, Abozer Y.
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 19-10-2022; MDPI
• Subjects: Acids; Alzheimer's disease; Animal cognition; Antioxidants; Bioavailability; Blueberries; Breast cancer; Cancer; Cardiovascular diseases; Cereals; Chemical compounds; Chronic illnesses; Flavonoids; Fruits; human health; Immunomodulation; In vivo methods and tests; Inflammation; Kinases; Legumes; Medical treatment; Metabolites; nanoformulations; nanonization; Neurological diseases; Neurotoxicity; Oxidative stress; Pharmacology; Polyphenols; Radiation; Review; Secondary metabolites; Vegetables
• ISSN: 2075-1729; 2075-1729
• DOI: 10.3390/life12101639

Polyphenols are the secondary metabolites synthesized by the plants as a part of defense machinery. Owing to their antioxidant, anti-inflammatory, anticancerous, antineoplastic, and immunomodulatory effects, natural polyphenols have been used for a long time to prevent and treat a variety of diseases. As a result, these phytochemicals may be able to act as therapeutic agents in treating cancer and cardiovascular and neurological disorders. The limited bioavailability of polyphenolic molecules is one issue with their utilization. For the purpose of increasing the bioavailability of these chemicals, many formulation forms have been developed, with nanonization standing out among them. The present review outlines the biological potential of nanoformulated plant polyphenolic compounds. It also summarizes the employability of various polyphenols as nanoformulations for cancer and neurological and cardiovascular disease treatment. Nanoencapsulated polyphenols, singular or in combinations, effective both in vitro and in vivo, need more investigation.