Basement membranes: structure, assembly and role in tumour angiogenesis

• Published in: Nature reviews. Cancer Vol. 3; no. 6; pp. 422 - 433
• Main Author: Kalluri, Raghu
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01-06-2003
• Subjects: Basement Membrane - metabolism; Basement Membrane - ultrastructure; Capillaries - physiology; Cell membranes; Collagen - metabolism; Control; Endothelium, Vascular - metabolism; Extracellular Matrix - metabolism; Extracellular Matrix Proteins - metabolism; Forecasting; Genetic aspects; Neoplasms - blood supply; Neoplasms - pathology; Neovascularization; Neovascularization, Pathologic - pathology; Physiological aspects; Risk factors; Structure; Tumors; United States
• ISSN: 1474-175X; 1474-1768
• DOI: 10.1038/nrc1094

In recent years, the basement membrane (BM)--a specialized form of extracellular matrix (ECM)--has been recognized as an important regulator of cell behaviour, rather than just a structural feature of tissues. The BM mediates tissue compartmentalization and sends signals to epithelial cells about the external microenvironment. The BM is also an important structural and functional component of blood vessels, constituting an extracellular microenvironment sensor for endothelial cells and pericytes. Vascular BM components have recently been found to be involved in the regulation of tumour angiogenesis, making them attractive candidate targets for potential cancer therapies.