Association of Aromatase With Bladder Cancer Stage and Long-Term Survival: New Insights Into the Hormonal Paradigm in Bladder Cancer

• Published in: Clinical genitourinary cancer Vol. 15; no. 2; pp. 256 - 262.e1
• Main Authors: Nguyen, Daniel P, O'Malley, Padraic, Al Hussein Al Awamlh, Bashir, Furrer, Marc-Alain, Mongan, Nigel P, Robinson, Brian D, Wang, Gerald J, Scherr, Douglas S
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-04-2017
• Subjects: Aged; Aromatase - metabolism; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Estrogen receptor beta; Estrogen Receptor beta - genetics; Estrogen Receptor beta - metabolism; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Hematology, Oncology and Palliative Medicine; Hormones; Humans; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Regulation; Stage; Survival Analysis; Tumor marker; Up-Regulation; Urinary Bladder Neoplasms - genetics; Urinary Bladder Neoplasms - metabolism; Urinary Bladder Neoplasms - pathology; Urology; Tumor marker; Stage; Regulation; Hormones; Estrogen receptor beta
• ISSN: 1558-7673; 1938-0682
• DOI: 10.1016/j.clgc.2016.05.017

Micro-Abstract Hormones may play a role in bladder cancer. We evaluated the impact of a novel marker, the enzyme aromatase, on characteristics of bladder cancer in 40 patients. We found that expression of this enzyme was associated with higher tumor stage as well as survival outcomes. Our preliminary results should encourage further investigations into the role of hormones in bladder cancer.