Reversible DNA micro-patterning using the fluorous effect

We describe a new method for the immobilisation of DNA into defined patterns with sub-micron resolution, using the fluorous effect. The method is fully reversible via a simple solvent wash, allowing the patterning, regeneration and re-patterning of surfaces with no degradation in binding efficiency...

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Bibliographic Details
Published in:	Chemical communications (Cambridge, England) Vol. 53; no. 21; p. 3094
Main Authors:	Flynn, Gabriella E, Withers, Jamie M, Macias, Gerard, Sperling, Justin R, Henry, Sarah L, Cooper, Jonathan M, Burley, Glenn A, Clark, Alasdair W
Format:	Journal Article
Language:	English
Published:	England 2017
Subjects:	DNA - chemistry Hydrocarbons, Fluorinated - chemistry Optical Imaging Surface Properties
Online Access:	Get more information
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Summary:	We describe a new method for the immobilisation of DNA into defined patterns with sub-micron resolution, using the fluorous effect. The method is fully reversible via a simple solvent wash, allowing the patterning, regeneration and re-patterning of surfaces with no degradation in binding efficiency following multiple removal/attachment cycles of different DNA sequences.
ISSN:	1364-548X
DOI:	10.1039/c7cc00288b