Polymorphism in the interleukin-10 gene is associated with overactive bladder phenotype associated with HTLV-1 infection

• Published in: Revista da Sociedade Brasileira de Medicina Tropical Vol. 52; p. e20180481
• Main Authors: Braz, Marcos, Oliveira, Joyce Moura, Rêgo, Jamile Leão, Carvalho, Edgar Marcelino de, Santos, Silvane Maria Braga, Castellucci, Léa Cristina
• Format: Journal Article
• Language: English
• Published: Brazil Sociedade Brasileira de Medicina Tropical - SBMT 01-01-2019; Sociedade Brasileira de Medicina Tropical (SBMT)
• Subjects: Adolescent; Adult; Case-Control Studies; Female; Genotype; HTLV-1; HTLV-I Infections - complications; HTLV-I Infections - genetics; Human T-lymphotropic virus 1; Humans; Interleukin-10 - genetics; Male; Middle Aged; Overactive bladder; Phenotype; Polymorphism, Single Nucleotide - genetics; SNP rs1800896 (-1082bp A/G); TROPICAL MEDICINE; Urinary Bladder, Overactive - etiology; Urinary Bladder, Overactive - genetics; Young Adult; SNP rs1800896 (-1082bp A/G); Overactive bladder; HTLV-1
• ISSN: 0037-8682; 1678-9849; 1678-9849
• DOI: 10.1590/0037-8682-0481-2018

Human T-cell lymphotropic virus type 1 (HTLV-1)-associated inflammatory diseases are not well understood; however, their clinical manifestations may be influenced by the host genetic background.
We genotyped 298 individuals with HTLV-1 and 380 controls for interleukin-10 (IL10) gene variants-rs3024496, rs1800871, rs1800896-and used logistic regression analysis to determine their association with clinical phenotypes.
No association with HTLV-1 infection was observed. However, allele A of rs1800896 (1082bp upstream) was associated with protection against neurological impairment, specifically overactive bladder (OR=0.447, 95% CI 0.28-0.70, p=0.001).
Our data suggests that IL10 regulation ameliorates neurological damage in HTLV-1 infections.