Anti-quorum sensing and anti-biofilm formation activities of plant extracts from South Korea

• Published in: Asian Pacific journal of tropical biomedicine Vol. 8; no. 8; pp. 411 - 417
• Main Authors: Choi, Okhee, Kang, Dong-Wan, Cho, Su, Lee, Yeyeong, Kang, Byeongsam, Bae, Juyoung, Kim, Seunghoe, Lee, Jeong, Lee, Seung, Kim, Jinwoo
• Format: Journal Article
• Language: English
• Published: Medknow Publications and Media Pvt. Ltd 01-08-2018; Institute of Agriculture & Life Science, Gyeongsang National University, Jinju 52828, Republic of Korea%Gyeonsangnam-do Agriculture Extension Services, Jinju 52733, Republic of Korea%Department of Plant Medicine, Gyeongsang National University, Jinju 52828, Republic of Korea%Division of Applied Life Science, Gyeongsang National University, Jinju 52828, Republic of Korea%National Institute of Horticultural and Herbal Science, Rural Development Administration, Eumseong Gun 27709, Republic of Korea%Institute of Agriculture & Life Science, Gyeongsang National University, Jinju 52828, Republic of Korea; Division of Applied Life Science, Gyeongsang National University, Jinju 52828, Republic of Korea; Wolters Kluwer Medknow Publications
• Subjects: biofilm formation; Biological products; cornus controversa; Ethanol; Fuel industry; Journalists; plant extracts; Plants (Organisms); Pseudomonas aeruginosa; quorum sensing; Quorum sensing; Biofilm formation; Plant extracts; Cornus controversa
• ISSN: 2221-1691
• DOI: 10.4103/2221-1691.239429

Objective: To investigate anti-quorum sensing (anti-QS) and anti-biofilm formation (anti- BF) activities of the ethanol extracts of 388 plants. Methods: The anti-QS activity of the plant extracts was evaluated by disc-diffusion assays using the bio-reporter strain, Chromobacterium violaceum CV017. Pseudomonas aeruginosa PAO1, Yersinia enterocolitica ATCC 9610, and Agrobacterium tumefaciens C58, which possess QS systems, were used to evaluate the anti- BF activity of the plant extracts. Results: Among 388 plant extracts, the Cornus controversa (C. controversa) and Cynanchum wilfordii extracts exhibited the strongest anti-QS activity. The C. controversa extract exhibited anti-BF activity against Pseudomonas aeruginosa, Yersinia enterocolitica and Agrobacterium tumefaciens, whereas the Cynanchum wilfordii extract exhibited no anti-BF activity against Pseudomonas aeruginosa. In addition, the C. controversa extract suppressed soft rot of cabbage. Conclusions: The C. controversa extract inhibits bacterial QS and BF, and is capable of controlling soft rot. Therefore, this extract has potential for the prevention and treatment of bacterial infections and for the development of alternatives to antibiotics.