AIDS-Associated Infections in Salivary Glands: Autopsy Survey of 60 Cases

• Published in: Clinical infectious diseases Vol. 22; no. 2; pp. 369 - 371
• Main Authors: Wagner, Randall P., Tian, Hongsheng, McPherson, Marcia J., Latham, Patricia S., Orenstein, Jan M.
• Format: Journal Article
• Language: English
• Published: Chicago, IL The University of Chicago Press 01-02-1996; University of Chicago Press
• Subjects: AIDS; AIDS-Related Opportunistic Infections - microbiology; AIDS-Related Opportunistic Infections - virology; AIDS/HIV; Autopsies; Biological and medical sciences; Cohort Studies; Cytomegalovirus; Cytomegalovirus infections; Cytomegalovirus Infections - virology; Female; HIV infections; human immunodeficiency virus; Humans; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Infections; Lung - microbiology; Lung - virology; Lungs; Male; Medical sciences; Opportunistic infections; Pancreas; Pancreas - microbiology; Pancreas - virology; Pancreatic Diseases - microbiology; Pancreatic Diseases - virology; Pneumocystis Infections - microbiology; Salivary glands; Submandibular Gland - microbiology; Submandibular Gland - virology; Submandibular Gland Diseases - microbiology; Submandibular Gland Diseases - virology; Human; Immunopathology; Protozoa; Opportunistic infection; Herpesviridae; Submandibular gland; Salivary gland; Pneumocystis carinii; AIDS; Parasitosis; Betaherpesvirinae; Immune deficiency; Human cytomegalovirus; Infection; Virus; Salivary gland disease; Etiology; Viral disease; Sporozoa
• ISSN: 1058-4838; 1537-6591
• DOI: 10.1093/clinids/22.2.369

We reviewed the autopsy findings for the submandibular glands of 60 patients with AIDS who were autopsied at the George Washington University Medical Center (Washington, DC) from 1982 to 1992. AIDS-associated infections in the submandibular glands were compared with those in the pancreas and lung. Cytomegalovirus intranuclear inclusions were found in 10 cases, and Pneumocystis carinii infection was found in one case. Disseminated mycobacterial and fungal infections were not identified in the submandibular gland, even in the presence of documented pancreatic and pulmonary infection (P < .05). Overall, the major salivary glands of patients with AIDS are less frequently involved with disseminated opportunistic infections than is either the lung or the pancreas (P < .01 and P < .001, respectively).