Impact of Bacillus Calmette–Guérin Moreau vaccine on lung remodeling in experimental asthma

• Published in: Respiratory physiology & neurobiology Vol. 189; no. 3; pp. 614 - 623
• Main Authors: Samary, Cynthia dos Santos, Antunes, Mariana Alves, Silva, Johnatas Dutra, da Silva, Adriana Lopes, de Araújo, Carla Cristina, Bakker-Abreu, Ilka, Diaz, Bruno Lourenço, Fernezlian, Sandra, Parra, Edwin Roger, Capelozzi, Vera Luiza, Silva, Pedro Leme, Lapa e Silva, José Roberto, Rocco, Patricia Rieken Macedo
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01-12-2013
• Subjects: Airway remodeling; Airway Remodeling - drug effects; Airway Remodeling - immunology; Airway resistance; Animals; Animals, Newborn; Asthma; Asthma - immunology; Asthma - pathology; Asthma - prevention & control; BCG vaccine; BCG Vaccine - pharmacology; BCG Vaccine - therapeutic use; Bronchoalveolar Lavage Fluid; Bronchoconstriction - drug effects; Disease Models, Animal; Eosinophilia; Forkhead Transcription Factors - genetics; Forkhead Transcription Factors - metabolism; Gene Expression Regulation; Lung - drug effects; Lung - pathology; Lung - physiopathology; Lung - ultrastructure; Male; Medical Education; Mice; Mice, Inbred BALB C; Microscopy, Electron, Transmission; Positive-Pressure Respiration; Pulmonary/Respiratory; Respiratory Muscles - pathology; Respiratory Muscles - ultrastructure; Airway resistance; Airway remodeling; BCG vaccine; Eosinophilia; Asthma
• ISSN: 1569-9048; 1878-1519
• DOI: 10.1016/j.resp.2013.07.025

Highlights • In the present model of allergic asthma, BCG-Moreau prevented airway inflammation. • BCG also minimized lung remodeling and airway hyperresponsiveness. • These beneficial effects of BCG may be related to the increase in Foxp3 and IL-10. • BCG acted in asthma independent of administration route and vaccination time.