Qualitative analysis of HIV and AIDS disease transmission: impact of awareness, testing and effective follow up [version 2; peer review: 3 approved]

• Published in: F1000 research Vol. 11; p. 1145
• Main Authors: Abiodun, Oluwakemi E., Adebimpe, Olukayode, Ndako, James, Oludoun, Olajumoke, Aladeitan, Benedicta, Adeniyi, Michael
• Format: Journal Article
• Language: English
• Published: London Faculty of 1000 Ltd 2023; F1000 Research Limited; F1000 Research Ltd
• Subjects: Acquired immune deficiency syndrome; AIDS; basic reproduction number; CD4 antigen; Condoms; defaulter lost to follow-up; Disease transmission; endemic equilibrium; eng; Epidemiology; HIV; HIV/AIDS; Human immunodeficiency virus; infection-free equilibrium; Mathematical models; next generation matrix; Public health; Viruses; HIV/AIDS; defaulter lost to follow-up; endemic equilibrium; next generation matrix; infection-free equilibrium; stability; basic reproduction number
• ISSN: 2046-1402; 2046-1402
• DOI: 10.12688/f1000research.123693.2

Background: Since the early 1980s, human immunodeficiency virus (HIV) and its accompanying acquired immunodeficiency syndrome (AIDS) have spread worldwide, becoming one of the world's major global health issues. From the beginning of the epidemic until 2020, about 79.3 million people became infected, with 36.3 million deaths due to AIDS illnesses. This huge figure is a result of those unaware of their status due to stigmatization and invariably spreading the virus unknowingly.
Methods: Qualitative analysis through a mathematical model that will address HIV unaware individuals and the effect of an increasing defaulter on the dynamics of HIV/AIDS was investigated. The impact of treatment and the effect of inefficient follow-up on the transmission of HIV/AIDS were examined. The threshold for the effective reduction of the unaware status of HIV through testing, in response to awareness, and the significance of effective non-defaulting in treatment commonly called defaulters loss to follow-up as these individuals contribute immensely to the spread of the virus due to their increase in CD4+ count was determined in this study. Stability analysis of equilibrium points is performed using the basic reproduction number $R_0$, an epidemiological threshold that determines disease eradication or persistence in viral populations.  We tested the most sensitive parameters in the basic reproduction numbers.
Results: The results portray that early identification and treatment only are inadequate for the illness to be eradicated, but effectively used of condom, strict adherence to treatment and counseling of and testing of pregnant women contribute to a decrease in infected HIV individuals.
Conclusions: Other control techniques, such as treatment adherence and effective condom usage, and reduction in vertical transmission cannot be over-emphasis to lessen the disease's burden. Policymakers must address these strategies through a series of public awareness campaigns about the dangers of not adhering to treatment procedures and patterns.