Hypnotic effects of deoxycorformycin in rats

Rats implanted with EEG and EMG electrodes were treated with deoxycoformycin (0.5 or 2.0 mg/kg, i.p.), and polygraphically recorded for 6 h. Deoxycoformycin is a potent inhibitor of adenosine deaminase and would be expected to elevate the levels of adenosine in the central nervous system. The 0.5 mg...

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Bibliographic Details
Published in:	Brain research Vol. 271; no. 2; p. 392
Main Authors:	Radulovacki, M, Virus, R M, Djuricic-Nedelson, M, Green, R D
Format:	Journal Article
Language:	English
Published:	Netherlands 25-07-1983
Subjects:	Adenosine Deaminase Inhibitors Animals Coformycin - analogs & derivatives Coformycin - pharmacology Dose-Response Relationship, Drug Male Nucleoside Deaminases - antagonists & inhibitors Pentostatin Rats Rats, Inbred Strains Ribonucleosides - pharmacology Sleep Stages - drug effects Sleep, REM - drug effects
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Summary:	Rats implanted with EEG and EMG electrodes were treated with deoxycoformycin (0.5 or 2.0 mg/kg, i.p.), and polygraphically recorded for 6 h. Deoxycoformycin is a potent inhibitor of adenosine deaminase and would be expected to elevate the levels of adenosine in the central nervous system. The 0.5 mg/kg dose of the drug increased REM sleep and reduced REM sleep latency while the dose of 2.0 mg/kg increased deep slow-wave sleep (S2). These results appear to be consistent with those reported previously for the adenosine analog, N6-(L-phenylisopropyl)-adenosine (L-PIA) and indicate a hypnotic role for adenosine.
ISSN:	0006-8993
DOI:	10.1016/0006-8993(83)90309-8