The regulation of antibiotic production in Streptomyces coelicolor A3(2)

• Published in: Microbiology (Reading) Vol. 142; no. 6; pp. 1335 - 1344
• Main Author: BIBB, M
• Format: Conference Proceeding Journal Article
• Language: English
• Published: Reading Society for General Microbiology 01-06-1996
• Subjects: Biological and medical sciences; Biology of microorganisms of confirmed or potential industrial interest; Biotechnology; Fundamental and applied biological sciences. Psychology; Genetics; Microbiology; Mission oriented research; Streptomyces coelicolor; Techniques used in virology; Virology; Actinomycetales; Antibiotic; Regulation(control); Streptomycetaceae; Streptomyces coelicolor; Bacteria; Actinomycetes; Review; Gene expression
• ISSN: 1350-0872; 1465-2080
• DOI: 10.1099/13500872-142-6-1335

Antibiotic production in streptomycetes generally coincides with the onset of morphological differentiation, and the isolation of mutants that are deficient in both processes suggests at least some common elements of genetic control. This article summarizes work carried out in the author's laboratory that has contributed to our current understanding of the regulation of antibiotic production in S. coelicolor. Much of this information has arisen from the application of gene cloning to streptomycetes. This same technology has revealed some unusual features of gene expression in streptomycetes that will also be reviewed.