Detoxification of the organophosphorus insecticide chlorfenvinphos by rat, rabbit and human liver enzymes

• Published in: Xenobiotica Vol. 16; no. 1; p. 87
• Main Authors: Hutson, D H, Logan, C J
• Format: Journal Article
• Language: English
• Published: England 01-01-1986
• Subjects: Animals; Chlorfenvinphos - metabolism; Chlorfenvinphos - toxicity; Cytochrome P-450 Enzyme System - metabolism; Humans; In Vitro Techniques; Inactivation, Metabolic; Insecticides - metabolism; Lethal Dose 50; Mice; Microsomes, Liver - enzymology; Rabbits; Rats; Rats, Inbred Strains
• ISSN: 0049-8254
• DOI: 10.3109/00498258609043509

A good inverse correlation between the acute oral toxicity of chlorfenvinphos and its rate of oxidative detoxification in the liver exists for rats, mice, rabbits and dogs. Measurements of the rates of oxidative metabolism (O-de-ethylation) by in vitro liver preparations from rat, rabbit and human have been compared. When the results are expressed in terms of cytochrome P450, as opposed to microsomal protein, detoxification by the human liver enzyme(s) is almost as effective as that by rabbit enzyme(s). The rabbit is relatively resistant to the acute toxic action of the insecticide.