Racial and ethnic variations in incidence and survival of cutaneous melanoma in the United States, 1999-2006

• Published in: Journal of the American Academy of Dermatology Vol. 65; no. 5; pp. S26.e1 - S26.e13
• Main Authors: Wu, Xiao-Cheng, MD, MPH, Eide, Melody J., MD, MPH, King, Jessica, MPH (CDC), Saraiya, Mona, MD, MPH (CDC), Huang, Youjie, MD, MPH, DrPH, Wiggins, Charles, PhD, Barnholtz-Sloan, Jill S., PhD, Martin, Nicolle, MD, MPH, Cokkinides, Vilma, PhD, Miller, Jacqueline, MD (CDC), Patel, Pragna, MD, MPH (CDC), Ekwueme, Donatus U., PhD (CDC), Kim, Julian, MD, FACS
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-11-2011
• Subjects: Adult; Age Factors; Aged; anatomic sites; cancer registry; Dermatology; Ethnic Groups - statistics & numerical data; Female; histology; Humans; Incidence; Male; melanoma; Melanoma - epidemiology; Melanoma - ethnology; Melanoma - etiology; Melanoma - prevention & control; Middle Aged; race and ethnicity; Registries; Sex Factors; Skin Neoplasms - epidemiology; Skin Neoplasms - ethnology; Skin Neoplasms - etiology; Skin Neoplasms - prevention & control; survival; Survival Analysis; United States - epidemiology; United States; AI/AN; ALM; anatomic sites; CDC; lentigo maligna melanoma; American Indians/Alaskan Natives; histology; Centers for Disease Control and Prevention; NPCR; SS2000; National Cancer Institute; SEER; Surveillance, Epidemiology, and End Results; superficial spreading melanoma; cancer registry; National Program of Cancer Registries; race and ethnicity; survival; SEER Summary Stage Manual-2000; melanoma; acral lentiginous melanoma; SSM; LMM; NCI; API; incidence; Asians/Pacific Islanders
• ISSN: 0190-9622; 1097-6787
• DOI: 10.1016/j.jaad.2011.05.034

Background Most melanoma studies use data from the National Cancer Institute Surveillance, Epidemiology, and End Results Program or individual cancer registries. Small numbers of melanoma cases have limited in-depth analyses for all racial and ethnic groups. Objective We sought to describe racial and ethnic variations in melanoma incidence and survival. Methods Incidence for invasive melanoma and 5-year melanoma-specific survival were calculated for whites, blacks, American Indians/Alaskan Natives, Asians/Pacific Islanders (API), and Hispanics using data from 38 population-based cancer registries. Results Incidence rates of melanoma were significantly higher for females than males among whites and Hispanics under 50 years of age and APIs under 40 years of age. White and black patients were older (median age: 59-63 years) compared with Hispanics, American Indians/Alaskan Natives, and API (median age: 52-56 years). The most common histologic type was acral lentiginous melanoma among blacks and superficial spreading melanoma among all other racial and ethnic groups. Hispanics had the highest incidence rate of acral lentiginous melanoma, significantly higher than whites and API. Nonwhites were more likely to have advanced and thicker melanomas at diagnosis and lower melanoma-specific survival compared with whites. Limitations Over 50% of melanoma cases did not have specified histology. The numbers of nonwhite patients were still relatively small despite broad population coverage (67% of United States). Conclusions Racial and ethnic differences in age at melanoma diagnosis, anatomic sites, and histologic types suggest variations in etiologic pathways. The high percentages of advanced and thicker melanomas among nonwhites highlight the need to improve melanoma awareness for all race and ethnicity in the United States.