The activity in the CNS catecholaminergic systems covaries with thyroid hormone metabolism in humans

• Published in: Journal of Neural Transmission Vol. 110; no. 12; pp. 1369 - 1373
• Main Authors: YHEDE, R, BLENNOW, K, FORSMAN, A, SODERSTROM, H
• Format: Journal Article
• Language: English
• Published: Wien Springer 01-12-2003; New York, NY Springer Nature B.V
• Subjects: Adult; Biogenic Monoamines - cerebrospinal fluid; Biogenic Monoamines - metabolism; Biological and medical sciences; Chromatography, High Pressure Liquid; Clinical Medicine; Dopamine; Fundamental and applied biological sciences. Psychology; Humans; Klinisk medicin; Male; Medical and Health Sciences; Medicin och hälsovetenskap; Neurologi; Neurology; Radioimmunoassay; serotonin; Thyroid Hormones - blood; thyroxine; triiodothyroxine; Vertebrates: nervous system and sense organs; Violence; Human; Dopamine; Serotonin; Dopamine agonist; Thyroxine; Neurotransmitter; Thyroid hormone; Catecholamine; Metabolism; triiodothyroxine
• ISSN: 0300-9564; 1435-1463
• DOI: 10.1007/s00702-003-0073-z

Do the CNS monoaminergic (MA) systems regulate thyroid hormone metabolism in humans? In 23 unmedicated, male, violent offenders without signs of thyroid disease, we found positive correlations between the catecholaminergic CSF metabolites HVA and MHPG and the peripheral T3/T4 ratio (rho=0.55, p=0.010 and 0.51, p=0.018), indicating that increased activity in the brain MA systems, especially the dopaminergic, is associated with increased peripheral thyroid hormone activity.