Palladium-Catalyzed Decarboxylative C-H Bond Arylation of Furans

• Published in: European journal of organic chemistry Vol. 2014; no. 20; pp. 4230 - 4233
• Main Authors: Pei, Kai, Jie, Xiaoming, Zhao, Huaiqing, Su, Weiping
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 01-07-2014; WILEY‐VCH Verlag; Wiley Subscription Services, Inc
• Subjects: C-H arylation; Cross-cou­pling; Decarboxylation; Palladium; Synthetic methods
• ISSN: 1434-193X; 1099-0690
• DOI: 10.1002/ejoc.201402278

A Pd/PCy3/Ag2CO3 (Cy = cyclohexyl) catalytic system was found to promote decarboxylative arylation through the combination of decarboxylation and C–H bond functionalization. This protocol features a good substrate scope of aromatic carboxylic acids as well as a broad range of functional groups and provides the products in high yields.
A Pd/PCy3/Ag2CO3 catalytic system promoting decarboxylative arylation through the combination of decarboxylation and C–H bond functionalization is reported. This protocol features a good substrate scope of aromatic carboxylic acids containing a broad range of functional groups and provides the products in high yields; Cy = cyclohexyl, tfa = trifluoroacetate.