Relationship between oxidative stress and lower urinary tract symptoms: results from a community health survey in Japan

• Published in: BJU international Vol. 123; no. 5; pp. 877 - 884
• Main Authors: Matsumoto, Teppei, Hatakeyama, Shingo, Imai, Atsushi, Tanaka, Toshikazu, Hagiwara, Kazuhisa, Konishi, Sakae, Okita, Kazutaka, Yamamoto, Hayato, Tobisawa, Yuki, Yoneyama, Tohru, Yoneyama, Takahiro, Hashimoto, Yasuhiro, Koie, Takuya, Nakaji, Shigeyuki, Ohyama, Chikara
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01-05-2019
• Subjects: 8‐OHdG; Adult; advanced glycation end product; Advanced glycosylation end products; Cross-Sectional Studies; Deoxyguanosine; Glycosylation; Health Surveys; Humans; Japan - epidemiology; lower urinary tract symptoms; Lower Urinary Tract Symptoms - complications; Lower Urinary Tract Symptoms - epidemiology; Lower Urinary Tract Symptoms - physiopathology; Middle Aged; nocturia; overactive bladder symptom score; Oxidative stress; Oxidative Stress - physiology; Prostate; Regression analysis; Skin; Surveys and Questionnaires; Urinary Bladder, Overactive - epidemiology; Urinary Bladder, Overactive - physiopathology; Urinary Incontinence, Urge - epidemiology; Urinary Incontinence, Urge - physiopathology; Urinary tract; Urine; Urogenital system; Japan; advanced glycation end product; nocturia; lower urinary tract symptoms; overactive bladder symptom score; oxidative stress; 8-OHdG
• ISSN: 1464-4096; 1464-410X
• DOI: 10.1111/bju.14535

Objective
To investigate the relationship between oxidative stress and lower urinary tract symptoms (LUTS) in a community‐dwelling population.
Materials and Methods
The cross‐sectional study included 1 113 people who participated in the Iwaki Health Promotion Project of 2015 in Hirosaki, Japan. LUTS were assessed using structured questionnaires, including the International Prostate Symptom Score (IPSS) and the Overactive Bladder Symptom Score (OABSS). IPSS > 7, OABSS > 5, nocturia score > 1, or urge incontinence score > 1 were defined as moderate to severe symptoms. 8‐Hydroxy‐2′‐deoxyguanosine (8‐OHdG) and advanced glycation end products (AGEs) were measured by urine analysis and skin autofluorescence, respectively. The relationship between oxidative stress and LUTS was investigated using logistic regression analyses.
Results
This study included 431 men and 682 women. AGEs and 8‐OHdG levels were significantly higher in severe forms of LUTS. Multivariate logistic regression analyses showed that AGE levels were significantly associated with a higher frequency of nocturia but were not associated with IPSS, OABSS or urge incontinence. No significant association was observed between LUTS and 8‐OHdG levels.
Conclusions
We observed a significant association between AGE levels and nocturia score > 1. Further research is necessary to clarify a possible causal relationship between oxidative stress and nocturia.