Mediators between oral dysbiosis and cardiovascular diseases

• Published in: European journal of oral sciences Vol. 126; no. S1; pp. 26 - 36
• Main Authors: Pietiäinen, Milla, Liljestrand, John M., Kopra, Elisa, Pussinen, Pirkko J.
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01-10-2018
• Subjects: Antibodies; Antigens; Arteriosclerosis; Atherogenesis; Atherosclerosis; Atherosclerosis - etiology; Attenuation; Bacteria; Biomarkers; Cardiovascular disease; Cardiovascular diseases; Cardiovascular Diseases - etiology; Cardiovascular Diseases - microbiology; Coronary artery; Coronary artery disease; Dentistry; Dysbacteriosis; Dysbiosis - complications; Endotoxemia; Gastrointestinal system; Gastrointestinal tract; Gum disease; Health risks; Heart diseases; Humans; infection; Inflammation; Lipid metabolism; Lipids; Low density lipoprotein; Metabolism; Microbiota; Microorganisms; Mouth - microbiology; Periodontitis; Periodontitis - complications; Periodontitis - microbiology; Risk analysis; Risk factors; Saliva; Serology; Virulence; Virulence factors; infection; risk factors; cardiovascular diseases; inflammation; periodontitis
• ISSN: 0909-8836; 1600-0722
• DOI: 10.1111/eos.12423

Clinical periodontitis is associated with an increased risk for cardiovascular diseases (CVDs) through systemic inflammation as the etiopathogenic link. Whether the oral microbiota, especially its quality, quantity, serology, and virulence factors, plays a role in atherogenesis is not clarified. Patients with periodontitis are exposed to bacteria and their products, which have access to the circulation directly through inflamed oral tissues and indirectly (via saliva) through the gastrointestinal tract, resulting in systemic inflammatory and immunologic responses. Periodontitis is associated with persistent endotoxemia, which has been identified as a notable cardiometabolic risk factor. The serology of bacterial biomarkers for oral dysbiosis is associated with an increased risk for subclinical atherosclerosis, prevalent and future coronary artery disease, and incident and recurrent stroke. In addition to species‐specific antibodies, the immunologic response includes persistent, cross‐reactive, proatherogenic antibodies against host‐derived antigens. Periodontitis may affect lipoprotein metabolism at all levels, and all lipoprotein classes are affected. Periodontitis or its bacterial signatures may be involved not only in increased storage of proatherogenic lipids but also in attenuation of the anti‐atherogenic processes, thereby putatively increasing the net risk of atherosclerosis. In this review we summarize possible molecular mediators between the dysbiotic oral microbiota and atherosclerotic processes.