Acute lymphoblastic leukemia

• Published in: Pediatric blood & cancer Vol. 68; no. S2; pp. e28371 - n/a
• Main Authors: Chang, John Han‐Chih, Poppe, Matthew M., Hua, Chia‐Ho, Marcus, Karen J., Esiashvili, Natia
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01-05-2021
• Subjects: Acute lymphoblastic leukemia; brain; Chemotherapy; Children; Dosage; Hematology; Hematopoietic stem cells; high‐dose chemotherapy; Leukemia; Lymphatic leukemia; Oncology; Pediatrics; Radiation therapy; Stem cell transplantation; Stem cells; testes; total body irradiation; leukemia; stem cell transplantation; radiation therapy; testes; total body irradiation; brain; chemotherapy; high-dose chemotherapy
• ISSN: 1545-5009; 1545-5017
• DOI: 10.1002/pbc.28371

The survival of patients with acute lymphoblastic leukemia (ALL) has improved significantly with the use of intensive multimodality treatment regimens including chemotherapy, high‐dose chemotherapy and stem cell rescue, and radiation therapy when indicated. This report summarizes the treatment strategies, especially radiation therapy in the Children's Oncology Group for children with ALL. Currently, radiation therapy is only indicated for children with high‐risk CNS involvement at diagnosis or relapse, testicular relapse and as part of the conditioning regimen for hematopoietic stem cell transplantation. Future research strategies regarding the indications for and dosages of radiation therapy and novel radiation techniques are discussed.