Use of darunavir in HIV-1-infected individuals in routine clinical practice from 2012 to 2016 in France

• Published in: Journal of antimicrobial chemotherapy Vol. 74; no. 11; pp. 3305 - 3314
• Main Authors: Potard, Valérie, Canestri, Ana, Gallien, Sebastien, Costagliola, Dominique
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01-11-2019; Oxford University Press (OUP)
• Subjects: Bacteriology; Cardiology and cardiovascular system; Emerging diseases; Human health and pathology; Infectious diseases; Life Sciences; Microbiology and Parasitology; Parasitology; Virology
• ISSN: 0305-7453; 1460-2091
• DOI: 10.1093/jac/dkz338

Abstract
Objectives
We assessed virological outcomes of darunavir use in France from 2012 to 2016, in three groups of people living with HIV (PLHIV): (i) antiretroviral (ARV)-naive PLHIV; (ii) ARV-experienced PLHIV switching to darunavir while failing therapy; and (iii) ARV-experienced PLHIV switching to darunavir while virologically controlled.
Methods
Virological success (VS) was defined as a plasma HIV-1 viral load (VL) <50 copies/mL and virological failure (VF) as two consecutive VL >50 copies/mL or one VL >50 copies/mL followed by a treatment switch prior to the next VL measurement. The cumulative incidence of VS was assessed considering darunavir discontinuation, loss to follow-up and death as competing risks, while estimates of cumulative incidence of VF accounted for loss to follow-up and death.
Results
Among the 3235 ARV-naive PLHIV initiating darunavir, the 4 year cumulative incidence of VS was 80.9% and was associated with lower VL and higher CD4 cell counts. Among the 3485 ARV-experienced PLHIV switching to darunavir while failing therapy, the 4 year cumulative incidence of VS was 82.2% and was associated with lower VL. Among the 3005 ARV-experienced PLHIV switching to darunavir while virologically controlled, the 4 year cumulative incidence of VF was 12.6%. The risk of VF was higher with darunavir monotherapy [subdistribution hazard ratio (sHR)=1.67, 95% CI 1.15–2.42] while no difference was observed with dual therapy (sHR = 1.00, 95% CI 0.71–1.42) relative to triple therapy or more.
Conclusions
Darunavir-containing regimens yielded similarly high rates of viral suppression in PLHIV whether they were ARV naive or ARV experienced switching to darunavir while failing therapy, or of maintaining VS in ARV-experienced PLHIV switching to darunavir while virologically controlled.