Recurring Thrombocytopenia Associated with Structured Treatment Interruption in Patients with Human Immunodeficiency Virus Infection

• Published in: Clinical infectious diseases Vol. 37; no. 5; pp. 723 - 725
• Main Authors: Ananworanich, Jintanat, Phanuphak, Nittaya, Nuesch, Reto, Apateerapong, Wichitra, Rojnuckarin, Ponlapat, Ubolyam, Sasiwimol, Phanuphak, Praphan, Ruxrungtham, Kiat
• Format: Journal Article
• Language: English
• Published: Chicago, IL The University of Chicago Press 01-09-2003; University of Chicago Press
• Subjects: Adult; AIDS; Antibodies; Antiretrovirals; Biological and medical sciences; CD4 Lymphocyte Count; Drug Administration Schedule; Hematologic and hematopoietic diseases; Highly active antiretroviral therapy; HIV; HIV infections; HIV Infections - drug therapy; HIV Infections - enzymology; HIV Protease Inhibitors - adverse effects; HIV Protease Inhibitors - therapeutic use; HIV/AIDS; Human viral diseases; Humans; Infections; Infectious diseases; Male; Medical sciences; Middle Aged; Platelet Count; Platelet diseases and coagulopathies; Platelets; Randomized Controlled Trials as Topic; Recurrence; Reverse Transcriptase Inhibitors - adverse effects; Reverse Transcriptase Inhibitors - therapeutic use; Thrombocytopenia; Thrombocytopenia - etiology; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Viruses; Human; Thrombocytopenia; Immunopathology; AIDS; Hemopathy; Immune deficiency; Infection; Case study; Numeration; Structured treatment interruption; Chemotherapy; Platelet; Treatment; Immunological investigation; Viral disease; T-Lymphocyte; Antiviral; Complication
• ISSN: 1058-4838; 1537-6591
• DOI: 10.1086/376989

In a structured treatment interruption (STI) trial, 3 of 23 patients in a CD4 cell count-guided treatment arm developed recurring thrombocytopenia associated with the interruption of antiretroviral therapy. All 3 patients had slightly low or normal platelet counts before initiating antiretroviral therapy. STI may play a role in inducing thrombocytopenia in patients with human immunodeficiency virus infection.